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CD6 Protein (CD6) (Fc Tag)

CD6 Spezies: Human Wirt: HEK-293 Cells Recombinant > 95 % as determined by reducing SDS-PAGE. Active
Produktnummer ABIN7317120
  • Target Alle CD6 Proteine anzeigen
    CD6
    Protein-Typ
    Recombinant
    Biologische Aktivität
    Active
    Spezies
    • 6
    • 4
    • 2
    • 1
    Human
    Quelle
    • 7
    • 3
    • 2
    • 1
    HEK-293 Cells
    Aufreinigungstag / Konjugat
    Dieses CD6 Protein ist gelabelt mit Fc Tag.
    Verwendungszweck
    Recombinant Human CD6/TP120 (Fc Tag)(Active)
    Sequenz
    Met 1-Glu398
    Produktmerkmale
    A DNA sequence encoding the human CD6 (NP_006716.3) (Met1-Glu398) was expressed with the Fc region of human IgG1 at the C-terminus.
    Reinheit
    > 95 % as determined by reducing SDS-PAGE.
    Endotoxin-Niveau
    < 1.0 EU per μg as determined by the LAL method.
    Biological Activity Comment
    Measured by the ability of the immobilized protein to support the adhesion of Jurkat human acute T cell leukemia cells.When 8x10E4 cells/well are added to CD6-Fc coated plates (10 μg/mL, 100 μL/well), approximately >70% will adhere after 60 minutes at 37°C.
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    Discover our top product CD6 Protein
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Please refer to the printed manual for detailed information.
    Buffer
    Lyophilized from sterile PBS, pH 7.4
    Lagerung
    4 °C,-20 °C,-80 °C
    Informationen zur Lagerung
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Target
    CD6
    Andere Bezeichnung
    CD6/TP120 (CD6 Produkte)
    Synonyme
    TP120 Protein, OX52 Protein, CD6 antigen Protein, CD6 molecule Protein, Cd6 molecule Protein, Cd6 Protein, CD6 Protein
    Hintergrund

    Background: T-cell differentiation antigen CD6, also known as TP120 and CD6, is a single-pass type I membrane protein which contains three SRCR domains. CD6 / TP120 is a cell surface glycoprotein expressed primarily on T cells, it may function as a costimulatory molecule and may play a role in autoreactive immune responses. CD6 / TP120 is expressed by thymocytes, mature T-cells, a subset of B-cells known as B-1 cells, and by some cells in the brain. CD6 ligand termed CD166 (previously known as activated leukocyte cell adhesion molecule, ALCAM ) has been identified and shown to be expressed on activated T cells, B cells, thymic epithelium, keratinocytes, and in rheumatoid arthritis synovial tissue. CD6 / TP120 binds to activated leukocyte cell adhesion molecule ( CD166 ), and is considered as a costimulatory molecule involved in lymphocyte activation and thymocyte development. CD6 / TP120 partially associates with the TCR / CD3 complex and colocalizes with it at the center of the mature immunological synapse (IS) on T lymphocytes. During thymic development CD6-dependent signals may contribute both to thymocyte survival, and to the overall functional avidity of selection in both man and mouse.

    Synonym: TP120

    Molekulargewicht
    67.3 kDa
    NCBI Accession
    NP_006716
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