Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

CD6 Protein (CD6) (His tag)

CD6 Spezies: Maus Wirt: HEK-293 Cells Recombinant > 90 % as determined by SDS-PAGE Active
Produktnummer ABIN7194910
  • Target Alle CD6 Proteine anzeigen
    CD6
    Protein-Typ
    Recombinant
    Biologische Aktivität
    Active
    Spezies
    • 7
    • 3
    • 2
    • 1
    Maus
    Quelle
    • 7
    • 3
    • 2
    • 1
    HEK-293 Cells
    Aufreinigungstag / Konjugat
    Dieses CD6 Protein ist gelabelt mit His tag.
    Verwendungszweck
    Recombinant Mouse CD6/TP120 Protein (His Tag)(Active)
    Sequenz
    Met 1-Gly396
    Produktmerkmale
    A DNA sequence encoding the extracellular domain of mouse CD6 (Q91WN5) (Met 1-Gly396) was expressed with a C-terminal polyhistidine tag.
    Reinheit
    > 90 % as determined by SDS-PAGE
    Endotoxin-Niveau
    < 1.0 EU per μg of the protein as determined by the LAL method.
    Biological Activity Comment
    Measured by the ability of the immobilized protein to support the adhesion of Jurkat human acute T cell leukemia cells.When 8 x 104 cells/well are added to mCD6-His coated plates (5μg/mL, 100 μL/well) , approximately more than 15% of cells will adhere after 60 minutes at 37°C.
    Top Product
    Discover our top product CD6 Protein
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Please refer to the printed manual for detailed information.
    Buffer
    Lyophilized from sterile PBS, pH 7.4
    Lagerung
    4 °C,-20 °C,-80 °C
    Informationen zur Lagerung
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Target
    CD6
    Andere Bezeichnung
    CD6/TP120 (CD6 Produkte)
    Synonyme
    TP120 Protein, OX52 Protein, CD6 antigen Protein, CD6 molecule Protein, Cd6 molecule Protein, Cd6 Protein, CD6 Protein
    Hintergrund

    Background: T-cell differentiation antigen CD6, also known as TP120 and CD6, is a single-pass type I membrane protein which contains three SRCR domains. CD6 / TP120 is a cell surface glycoprotein expressed primarily on T cells, it may function as a costimulatory molecule and may play a role in autoreactive immune responses. CD6 / TP120 is expressed by thymocytes, mature T-cells, a subset of B-cells known as B-1 cells, and by some cells in the brain. CD6 ligand termed CD166 (previously known as activated leukocyte cell adhesion molecule, ALCAM ) has been identified and shown to be expressed on activated T cells, B cells, thymic epithelium, keratinocytes, and in rheumatoid arthritis synovial tissue. CD6 / TP120 binds to activated leukocyte cell adhesion molecule ( CD166 ), and is considered as a costimulatory molecule involved in lymphocyte activation and thymocyte development. CD6 / TP120 partially associates with the TCR / CD3 complex and colocalizes with it at the center of the mature immunological synapse (IS) on T lymphocytes. During thymic development CD6-dependent signals may contribute both to thymocyte survival, and to the overall functional avidity of selection in both man and mouse.

    Synonym: CD6 antigen; Cd6

    Molekulargewicht
    42.6 kDa
    UniProt
    Q91WN5
Sie sind hier:
Kundenservice