C5A Protein

Produktnummer ABIN7319677

Produktdetails

Target: C5A (C5a) (Complement Component 5a (C5a))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Escherichia coli (E. coli)

Verwendungszweck: Recombinant Human Complement C5a Protein

Sequenz: Thr678-Arg751

Produktmerkmale: Recombinant Human C5a is produced by our E.coli expression system and the target gene encoding Thr678-Arg751 is expressed.

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: C5A (C5a) (Complement Component 5a (C5a))

Andere Bezeichnung: Complement C5a (C5a Produkte)

Synonyme: C5a Protein, C5b Protein, CPAMD4 Protein, Hc Protein, RGD1561905 Protein, complement C5 Protein, C5 Protein

Hintergrund:

Background: Human Complement 5a (C5a) is an enzymatically generated glycoprotein that belongs to a family of structurally and functionally related proteins known as anaphylatoxins. C5a is a 74 amino acid (aa) peptide that is created by the activity of C5a convertase on the C5 α-chain. Human C5a has four α-helices plus three intrachain disulfide bonds that create a triple loop structure. Human C5a is 60 % and 54 % aa identical to mouse and rat C5a, respectively. C5a binds to a signaling G-protein coupled receptor (C5aR/CD88) and a nonsignaling GPCR termed C5L2. Activation of Cd88 results in neutrophil chemotaxis and endothelial cell activation. It also triggers an oxidative burst in macrophages and neutrophils, and induces release of histamine in basophils and mast cells.

Synonym: Complement C5, C5a anaphylatoxin, C5a,CPAMD4,ECLZB,C5Da

Molekulargewicht: 8.4 kDa

UniProt: P01031

Pathways: Komplementsystem, Carbohydrate Homeostasis