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Contactin 1 Protein (CNTN1) (His tag)

CNTN1 Spezies: Maus Wirt: HEK-293 Cells Recombinant > 90 % as determined by SDS-PAGE
Produktnummer ABIN7195254
  • Target Alle Contactin 1 (CNTN1) Proteine anzeigen
    Contactin 1 (CNTN1)
    Protein-Typ
    Recombinant
    Spezies
    • 4
    • 2
    • 2
    Maus
    Quelle
    • 5
    • 2
    • 1
    HEK-293 Cells
    Aufreinigungstag / Konjugat
    Dieses Contactin 1 Protein ist gelabelt mit His tag.
    Verwendungszweck
    Recombinant Mouse Contactin 1/CNTN1 Protein (His Tag)
    Sequenz
    Met1-Leu1000
    Produktmerkmale
    A DNA sequence encoding the mouse CNTN1 (NP_031753.1) (Met1-Leu1000) was expressed with a C-terminal polyhistidine tag.
    Reinheit
    > 90 % as determined by SDS-PAGE
    Endotoxin-Niveau
    < 1.0 EU per μg of the protein as determined by the LAL method.
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Please refer to the printed manual for detailed information.
    Buffer
    Lyophilized from sterile PBS, pH 7.4
    Lagerung
    4 °C,-20 °C,-80 °C
    Informationen zur Lagerung
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Target
    Contactin 1 (CNTN1)
    Andere Bezeichnung
    Contactin 1/CNTN1 (CNTN1 Produkte)
    Synonyme
    F3 Protein, GP135 Protein, AW495098 Protein, CNTN Protein, F3cam Protein, F3/F11 Protein, cntn-A Protein, F11 Protein, CNTN1 Protein, cntn1 Protein, contactin 1 Protein, contactin 1 L homeolog Protein, contactin 1a Protein, CNTN1 Protein, Cntn1 Protein, cntn1.L Protein, cntn1a Protein
    Hintergrund

    Background: Contactins are a subgroup of molecules belonging to the immunoglobulin superfamily that are expressed exclusively in the nervous system. The subgroup consists of six members: Contactin-1, Contactin-2 (TAG-1), Contactin-3 (BIG-1), BIG-2, Contactin-5 (NB-2) and NB-3. Since their identification in the late 1980s, Contactin-1 and Contactin-2 have been studied extensively. Axonal expression and the neurite extension activity of Contactin-1 and Contactin-2 attracted researchers to study the function of these molecules in axon guidance during development. Contactin-1 and Contactin-2 have come to be known as the principal molecules in the function and maintenance of myelinated neurons. In contrast, the function of the other four members of this subgroup remained unknown until recently. Contactin-1 is a cell surface adhesion molecule that is normally expressed by neurons and oligodendrocytes. Particularly high levels of Contactin-1 are present during brain development. Contactin-1 and Contactin-2 are differentially expressed in a number of neuronal tissues during development, and they interact with several ligands including Nr-CAM, L1, NCAM, neurocan, phosphacan, and tenascin. As a cell adhesion molecule, Contactin-1 plays a role in the formation of axon connections in the developing nervous system. It was demonstrated that Contactin-1 participates in signal pathways via its association with Contactin-associated protein (CNTNAP1), receptor protein tyrosine phosphatase beta (RPTPb) and NOTCH1. Contactin-1 is also involved in paranodal axo-glial junction formation and oligodendrocytes generation. Furthermore, studies indicated that Contactin-1 functions importantly in the invasion and metastasis of lung adenocarcinoma cells. Contactin-1 may also significantly influence the functional expression and distribution of Na+ channels in neurons.

    Synonym: AW495098,CNTN,F3cam,usl

    Molekulargewicht
    110.5 kDa
    NCBI Accession
    NP_031753
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