Ectodysplasin A2 Receptor Protein (EDA2R) (His tag)
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- Target Alle Ectodysplasin A2 Receptor (EDA2R) Proteine anzeigen
- Ectodysplasin A2 Receptor (EDA2R)
- Protein-Typ
- Recombinant
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Spezies
- Maus
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Quelle
- Human Cells
- Aufreinigungstag / Konjugat
- Dieses Ectodysplasin A2 Receptor Protein ist gelabelt mit His tag.
- Verwendungszweck
- Recombinant Mouse XEDAR/EDA2R Protein (His Tag)
- Sequenz
- Met1-Thr138
- Produktmerkmale
- Recombinant Mouse Ectodysplasin A2 Receptor is produced by our Mammalian expression system and the target gene encoding Met1-Thr138 is expressed with a 6His tag at the C-terminus.
- Reinheit
- > 95 % as determined by SDS-PAGE
- Endotoxin-Niveau
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product EDA2R Protein
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- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Rekonstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
- Lagerung
- 4 °C,-20 °C,-80 °C
- Informationen zur Lagerung
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Target
- Ectodysplasin A2 Receptor (EDA2R)
- Andere Bezeichnung
- XEDAR/EDA2R (EDA2R Produkte)
- Synonyme
- EDA-A2R Protein, EDAA2R Protein, TNFRSF27 Protein, XEDAR Protein, 9430060M22Rik Protein, Xedar Protein, RGD1564025 Protein, ectodysplasin A2 receptor Protein, EDA2R Protein, Eda2r Protein
- Hintergrund
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Background: Tumor necrosis factor receptor superfamily member 27, also known as XEDAR and EDA2R, is a type III transmembrane protein of the TNFR superfamily. EDA2R consists of extracellular domain (ECD) with 3 cysteine-rich repeats and a single transmembrane domain but lacks an N-terminal signal peptide. EDA2R is widely expressed, notably in embryonic basal epidermal cells and maturing hair follicles. Even though it does not contain a cytoplasmic death domain, EDA2R can associate with Fas and induce EDA-A2 dependent apoptosis. Its transcription is directly induced by p53, and it mediated cell death is p53 dependent. it is down-regulated in breast, colon, and lung cancers, particularly in cases with p53 mutations. It also plays a role in EDA-A2 induced skeletal muscle degeneration and osteoblast differentiation. Mutations in the EDA gene are associated with the X-linked form of Hypohidrotic Ectodermal Dysplasia (HED), a disease typically characterized by abnormal hair, teeth and sweat glands.
Synonym: Ectodysplasin A2 receptor, EDA-A2 receptor, EDA-A2R, Tumor necrosis factor receptor superfamily member XEDAR, Tumor necrosis factor receptor superfamily member 27, X-linked ectodysplasin-A2 receptor,EDAA2R, TNFRSF27, XEDAR,EDAR2
- Molekulargewicht
- 16.4 kDa
- UniProt
- Q8BX35
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