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ESAM Protein

ESAM Spezies: Human Wirt: HEK-293 Cells Recombinant > 92 % as determined by reducing SDS-PAGE.
Produktnummer ABIN7317973
  • Target Alle ESAM Proteine anzeigen
    ESAM (Endothelial Cell Adhesion Molecule (ESAM))
    Protein-Typ
    Recombinant
    Spezies
    • 9
    • 3
    • 2
    • 1
    Human
    Quelle
    • 6
    • 5
    • 2
    • 1
    • 1
    HEK-293 Cells
    Verwendungszweck
    Recombinant Human ESAM Protein
    Sequenz
    Met 1-Ala 248
    Produktmerkmale
    The mature form of human ESAM (NP_620411.2) extracellular domain (Met 1-Ala 248) with five amino acids (DDDDK) at the C-terminus was expressed and purified.
    Reinheit
    > 92 % as determined by reducing SDS-PAGE.
    Endotoxin-Niveau
    < 1.0 EU per μg as determined by the LAL method.
    Top Product
    Discover our top product ESAM Protein
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Please refer to the printed manual for detailed information.
    Buffer
    Lyophilized from sterile 100 mM NaCl, 50 mM Tris, pH 7.5
    Lagerung
    4 °C,-20 °C,-80 °C
    Informationen zur Lagerung
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Target
    ESAM (Endothelial Cell Adhesion Molecule (ESAM))
    Andere Bezeichnung
    ESAM (ESAM Produkte)
    Synonyme
    ESAM Protein, sc:d0254 Protein, W117m Protein, 2310008D05Rik Protein, Esam1 Protein, endothelial cell adhesion molecule Protein, endothelial cell adhesion molecule a Protein, endothelial cell-specific adhesion molecule Protein, ESAM Protein, esama Protein, Esam Protein
    Hintergrund

    Background: Endothelial cell-selective adhesion molecule (ESAM) is a member of JAM family of immunoglobulin superfamily and consists of one V-type and one C2-type immunoglobulin domain, as well as a hydrophobic signal sequence, a single transmembrane region, and a cytoplasmic domain. It is specifically expressed at endothelial tight junctions and on activated platelets. ESAM at endothelial tight junctions participates in the migration of neutrophils through the vessel wall, possibly by influencing endothelial cell contacts. The adaptor protein membrane-associated guanylate kinase MAGI-1 has been identified as an intracellular binding partner of ESAM. Previous studies have indicated that ESAM regulates angiogenesis in the primary tumor growth and endothelial permeability. It suggest that ESAM has a redundant functional role in physiological angiogenesis but serves a unique and essential role in pathological angiogenic processes such as tumor growth.

    Synonym: W117m

    Molekulargewicht
    24.5 kDa
    NCBI Accession
    NP_620411
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