EGFR Protein (AA 668-1210) (GST tag,His tag)
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- Target Alle EGFR Proteine anzeigen
- EGFR (Epidermal Growth Factor Receptor (EGFR))
- Protein-Typ
- Recombinant
- Biologische Aktivität
- Active
- Proteineigenschaft
- AA 668-1210
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Spezies
- Human
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Quelle
- Baculovirus infected Insect Cells
- Aufreinigungstag / Konjugat
- Dieses EGFR Protein ist gelabelt mit GST tag,His tag.
- Verwendungszweck
- Recombinant Human EGFR/ErbB1 Protein (aa 668-1210, His&GST Tag)(Active)
- Sequenz
- Met 668-Ala 1210
- Produktmerkmale
- A DNA sequence encoding the cytoplasmic domain (Met 668-Ala 1210) of human EGFR (NP_005219) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
- Reinheit
- > 85 % as determined by reducing SDS-PAGE.
- Endotoxin-Niveau
- < 1.0 EU per μg of the protein as determined by the LAL method.
- Biological Activity Comment
- The specific activity was determined to be 105 nmol/min/mg using Poly(Glu:Tyr) 4:1 as substrate.
- Top Product
- Discover our top product EGFR Protein
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Epidermal Growth Factor Receptor (EGFR) (AA 25-645) protein (His-Avi Tag)
EGFR Spezies: Human Wirt: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Epidermal Growth Factor Receptor (EGFR) protein (His-Avi Tag,Biotin)EGFR Spezies: Human Wirt: HEK-293 Cells Recombinant > 95% as determined by Tris-Bis PAGE,> 95% as determined by HPLC
Epidermal Growth Factor Receptor (EGFR) (AA 25-645) protein (Fc Tag)EGFR Spezies: Human Wirt: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Epidermal Growth Factor Receptor (EGFR) (AA 25-645) (Active) protein (Fc Tag)EGFR Spezies: Human Wirt: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
Epidermal Growth Factor Receptor (EGFR) (AA 25-645) (Active) protein (His tag,AVI tag,Biotin)EGFR Spezies: Human Wirt: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
Epidermal Growth Factor Receptor (EGFR) (AA 25-378) (Active) protein (His tag,AVI tag,Biotin)EGFR Spezies: Human Wirt: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Func Active
Epidermal Growth Factor Receptor (EGFR) (AA 25-645) protein (His tag)EGFR Spezies: Rhesusaffen Wirt: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Epidermal Growth Factor Receptor (EGFR) (AA 25-647) protein (His tag)EGFR Spezies: Maus Wirt: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Epidermal Growth Factor Receptor (EGFR) (AA 1-405) protein (GST tag)EGFR Spezies: Human Wirt: Wheat germ Recombinant WB, ELISA, AA, AP
Epidermal Growth Factor Receptor (EGFR) (AA 25-645) protein (His tag)EGFR Spezies: Human Wirt: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. ELISA
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- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Frozen, Liquid
- Buffer
- Supplied as sterile 20 mM Tris, 500 mM NaCl, 10 % glycerol, pH 7.4
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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- Target
- EGFR (Epidermal Growth Factor Receptor (EGFR))
- Andere Bezeichnung
- EGFR/ErbB1 (EGFR Produkte)
- Hintergrund
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Background: As a member of the epidermal growth factor receptor (EGFR) family; EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF; amphiregulin; TGF-α; betacellulin; etc. EGFR protein plays a crucial role in signaling pathway in the regulation of cell proliferation; survival and differentiation. Binding of a ligand induces EGFR protein homo- or heterodimerization; the subsequent tyrosine autophosphorylation and initiates various down stream pathways (MAPK; PI3K/PKB and STAT). In addition; EGFR signaling also has been shown to exert action on carcinogenesis and disease progression; and thus EGFR protein is proposed as a target for cancer therapy currently.Immune Checkpoint Immunotherapy Cancer Immunotherapy Targeted Therapy
Synonym: ERBB;ERBB1;HER1;mENA;NISBD2;PIG61
- Molekulargewicht
- 89.1 kDa
- NCBI Accession
- NP_005219
- Pathways
- NF-kappaB Signalweg, RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Stem Cell Maintenance, Hepatitis C, Positive Regulation of Response to DNA Damage Stimulus, Interaction of EGFR with phospholipase C-gamma, Thromboxane A2 Receptor Signaling, EGFR Downregulation, S100 Proteine
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