Ezrin Protein (EZR)
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- Target Alle Ezrin (EZR) Proteine anzeigen
- Ezrin (EZR)
- Protein-Typ
- Recombinant
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Spezies
- Human
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Quelle
- Escherichia coli (E. coli)
- Verwendungszweck
- Recombinant Human Ezrin/EZR Protein
- Sequenz
- Met1-Leu586
- Produktmerkmale
- Recombinant Human Ezrin is produced by our E.coli expression system and the target gene encoding Met1-Leu586 is expressed.
- Reinheit
- > 95 % as determined by reducing SDS-PAGE.
- Endotoxin-Niveau
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product EZR Protein
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- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Rekonstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from a 0.2 μm filtered solution of 10 mM Hepes, pH 7.4.
- Lagerung
- 4 °C,-20 °C,-80 °C
- Informationen zur Lagerung
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Target
- Ezrin (EZR)
- Andere Bezeichnung
- Ezrin/EZR (EZR Produkte)
- Synonyme
- CVIL Protein, CVL Protein, VIL2 Protein, ezr Protein, vil2 Protein, wu:fc05c03 Protein, wu:fj31d06 Protein, cvil Protein, cvl Protein, Vil2 Protein, AW146364 Protein, R75297 Protein, p81 Protein, ezr.S Protein, ezrin Protein, ezrin b Protein, ezrin L homeolog Protein, EZR Protein, ezrb Protein, ezr Protein, Ezr Protein, ezr.L Protein
- Hintergrund
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Background: Ezrin is expressed in cerebral cortex, basal ganglia, hippocampus, hypophysis, and optic nerve. The N-terminus of ezrin contains a FERM domain which is further subdivided into three subdomains. The C-terminus contain a ERM domain. As a member of the ERM protein family, Ezrin serves as an intermediate between the plasma membrane and the actin cytoskeleton. It plays a key role in cell surface structure adhesion, migration, and organization. Ezrin probably involved in connections of major cytoskeletal structures to the plasma membrane. The N-terminal FERM domain strongly binds sodium-hydrogen exchanger regulatory factor (NHERF) proteins (involving long-range allostery). The C-terminal binds to actin, phosphatidylinositol bis-phosphate (PIP2) and membrane proteins like CD44 and ICAM-2. In epithelial cells, Ezrin is required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, Ezrin is required for normal macropinocytosis.
Synonym: Ezrin, Cytovillin, Villin-2, p81, EZR, VIL2
- Molekulargewicht
- 69.4 kDa
- UniProt
- P15311
- Pathways
- Maintenance of Protein Location
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