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GNS Protein (His tag)

GNS Spezies: Human Wirt: Human Cells Recombinant > 95 % as determined by reducing SDS-PAGE.
Produktnummer ABIN7318800
  • Target Alle GNS Proteine anzeigen
    GNS (Glucosamine (N-Acetyl)-6-Sulfatase (GNS))
    Protein-Typ
    Recombinant
    Spezies
    Human
    Quelle
    • 2
    • 1
    • 1
    Human Cells
    Aufreinigungstag / Konjugat
    Dieses GNS Protein ist gelabelt mit His tag.
    Verwendungszweck
    Recombinant Human GNS Protein (His Tag)
    Sequenz
    Val37-Leu552
    Produktmerkmale
    Recombinant Human N-Acetylglucosamine-6-Sulfatase is produced by our Mammalian expression system and the target gene encoding Val37-Leu552 is expressed with a 6His tag at the C-terminus.
    Reinheit
    > 95 % as determined by reducing SDS-PAGE.
    Endotoxin-Niveau
    < 1.0 EU per μg as determined by the LAL method.
    Top Product
    Discover our top product GNS Protein
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Frozen, Liquid
    Buffer
    Supplied as a 0.2 μm filtered solution of 20 mM TrisHCl, 150 mM NaCl,10 % Glycerol, pH 8.0.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
  • Target
    GNS (Glucosamine (N-Acetyl)-6-Sulfatase (GNS))
    Andere Bezeichnung
    GNS (GNS Produkte)
    Synonyme
    G6S Protein, 2610016K11Rik Protein, AU042285 Protein, C87209 Protein, N28088 Protein, NV14559 Protein, N-acetylglucosamine-6-sulfatase Protein, zgc:114066 Protein, gns Protein, wu:fi20h10 Protein, zgc:55370 Protein, glucosamine (N-acetyl)-6-sulfatase Protein, glucosamine (N-acetyl)-6-sulfatase S homeolog Protein, glucosamine (N-acetyl)-6-sulfatase a Protein, N-acetylglucosamine-6-sulfatase Protein, glucosamine (N-acetyl)-6-sulfatase (Sanfilippo disease IIID), b Protein, GNS Protein, Gns Protein, gns.S Protein, gns Protein, gnsa Protein, CpipJ_CPIJ000745 Protein, Sros_7372 Protein, VDBG_04409 Protein, Halhy_3165 Protein, gnsb Protein
    Hintergrund

    Background: N-Acetylglucosamine-6-Sulfatase is a member of the Sulfatase family. N-Acetylglucosamine-6-Sulfatase is required for the lysosomal degradation of the Glycosaminoglycans (GAG) Heparan Sulfate and Keratan Sulfate. N-Acetylglucosamine-6-Sulfatase hydrolyzes the 6-Sulfate groups of the N-Acetyl-D-Glucosamine 6-Sulfate units of Heparan Sulfate and Keratan Sulfate. N-Acetylglucosamine-6-Sulfatase binds 1 Calcium ion per subunit. N-Acetylglucosamine-6-Sulfatase deficiency are the cause of Mucopolysaccharidosis Type 3D (MPS3D), an inborn error leading to lysosomal accumulation of heparan sulfate. MPS3D has profound mental deterioration, hyperactivity, and relatively mild somatic manifestations.

    Synonym: N-Acetylglucosamine-6-Sulfatase, Glucosamine-6-Sulfatase, G6S, GNS

    Molekulargewicht
    59.4 kDa
    UniProt
    P15586
    Pathways
    Glycosaminoglycan Metabolic Process
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