Growth Hormone 1 Protein (GH1)

Produktnummer ABIN7196005

Produktdetails

Target: Growth Hormone 1 (GH1)

Protein-Typ: Recombinant

Biologische Aktivität: Active

Spezies: Human

Quelle: Escherichia coli (E. coli)

Verwendungszweck: Recombinant Human GH1/Growth hormone 1 Protein (Active)

Sequenz: Phe27-Phe217

Produktmerkmale: A DNA sequence encoding the human GH1 (P01241) (Phe27-Phe217) was expressed.

Reinheit: > 90 % as determined by reducing SDS-PAGE.

Biological Activity Comment: Measured by its ability to promote proliferation of INS-1 cells.The ED50 for this effect is 0.2-1 ng/mL.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: Growth Hormone 1 (GH1)

Andere Bezeichnung: GH1/Growth hormone 1 (GH1 Produkte)

Hintergrund:

Background: The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation, an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed in the pituitary but not in placental tissue as is the case for the other four genes in the growth hormone locus. Mutations in or deletions of the gene lead to growth hormone deficiency and short stature.

Synonym: GH,GH-N,GH1,GHB5,GHN,Growth hormone 1,hGH-N,IGHD1B

Molekulargewicht: 22.1 kDa

UniProt: P01241

Pathways: NF-kappaB Signalweg, JAK-STAT Signalweg, Intracellular Steroid Hormone Receptor Signaling Pathway, Peptide Hormone Metabolism, Regulation of Intracellular Steroid Hormone Receptor Signaling, Regulation of Hormone Metabolic Process, Response to Growth Hormone Stimulus, Regulation of Hormone Biosynthetic Process