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FIL1h Protein

FIL1h Spezies: Maus Wirt: Escherichia coli (E. coli) Recombinant > 95 % as determined by SDS-PAGE
Produktnummer ABIN7320596
  • Target Alle FIL1h Produkte
    FIL1h (Interleukin 1 eta (FIL1h))
    Protein-Typ
    Recombinant
    Spezies
    • 7
    • 4
    Maus
    Quelle
    • 9
    • 1
    • 1
    Escherichia coli (E. coli)
    Verwendungszweck
    Recombinant Mouse Interleukin-36b/IL-36b Protein
    Sequenz
    Ser31-Lys183
    Produktmerkmale
    Recombinant Mouse Interleukin-36 beta is produced by our E.coli expression system and the target gene encoding Ser31-Lys183 is expressed.
    Reinheit
    > 95 % as determined by SDS-PAGE
    Endotoxin-Niveau
    < 1.0 EU per μg as determined by the LAL method.
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Please refer to the printed manual for detailed information.
    Buffer
    Lyophilized from a 0.2 μm filtered solution of 20 mM Tris,150 mM Nacl,1 mM EDTA, pH 8.0.
    Lagerung
    4 °C,-20 °C,-80 °C
    Informationen zur Lagerung
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Target
    FIL1h (Interleukin 1 eta (FIL1h))
    Andere Bezeichnung
    Interleukin-36b/IL-36b (FIL1h Produkte)
    Synonyme
    2310043N20Rik Protein, Il36b Protein, FIL1 Protein, FIL1-(ETA) Protein, FIL1H Protein, FILI-(ETA) Protein, IL-1F8 Protein, IL-1H2 Protein, IL1-ETA Protein, IL1F8 Protein, IL1H2 Protein, Il1f8 Protein, interleukin 1 family, member 8 Protein, interleukin 36 beta Protein, interleukin 36, beta Protein, Il1f8 Protein, IL36B Protein, Il36b Protein
    Hintergrund

    Background: Mouse Interleukin 36 beta (IL-36B)is a member of the IL-1 family of proteins. It is a cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. IL-36B is synthesized in several cells including resting and activated monocytes, and B cells. The receptor for IL-36 beta is thought to be a combination of IL-1 Rrp2 and IL-1 RAcP. Interleukin 36 beta is one part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response, similar to the IL-1 system with which it shares the coreceptor IL1RAP. Interleukin 36 beta are involved in a number of fundamental biological processes such as stimulating production of interleukin-6 and interleukin-8 in synovial fibrobasts, articular chondrocytes and mature adipocytes, inducing expression of a number of antimicrobial peptides including beta-defensin 4 and beta-defensin 103 as well as a number of matrix metalloproteases , inducing the production of proinflammatory cytokines in bone marrow-derived dendritic cells (BMDCs), including IL-12, Il-1 beta, IL-6, TNF-alpha and IL-23, and activating p38 MAPK phosphorylation in BMDCs.Moreover, interleukin 36 beta may be involved in skin inflammatory response by acting on keratinocytes, dendritic cells, and indirectly on T cells to drive tissue infiltration, cell maturation and cell proliferation. It plays an important role in dendritic cell maturation by stimulating the surface expression of CD80, CD86 and MHC class II and inducing the production of IFN-gamma, IL-4 and IL-17 by T helper 1 (Th1) cells, cultured CD4+ T cells and splenocytes.

    Synonym: Il36b,Interleukin-36 beta,Interleukin-1 family member 8,IL-1F8,Fil1e, Il1f8

    Molekulargewicht
    17.6 kDa
    UniProt
    Q9D6Z6
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