IL6RA Protein (Fc Tag,ECD)
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- Target Alle IL6RA Proteine anzeigen
- IL6RA (Interleukin 6 Receptor, alpha (IL6RA))
- Protein-Typ
- Recombinant
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Spezies
- Ratte
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Quelle
- HEK-293 Cells
- Aufreinigungstag / Konjugat
- Dieses IL6RA Protein ist gelabelt mit Fc Tag,ECD.
- Verwendungszweck
- Recombinant Rat IL6RA/CD126 Protein (Fc tag, ECD)
- Sequenz
- Met1-Pro364
- Produktmerkmale
- A DNA sequence encoding the rat Il6r (NP_058716.2) (Met1-Pro364) was expressed with the Fc region of human IgG1 at the C-terminus.
- Reinheit
- > 90 % as determined by SDS-PAGE
- Endotoxin-Niveau
- < 1.0 EU per μg protein as determined by the LAL method.
- Top Product
- Discover our top product IL6RA Protein
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- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Rekonstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from sterile PBS, pH 7.4
- Lagerung
- 4 °C,-20 °C,-80 °C
- Informationen zur Lagerung
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Target
- IL6RA (Interleukin 6 Receptor, alpha (IL6RA))
- Andere Bezeichnung
- IL6RA/CD126 (IL6RA Produkte)
- Synonyme
- IL6R1 Protein, Il6ra Protein, CD126 Protein, IL-6R-1 Protein, IL-6RA Protein, IL6Q Protein, IL6RA Protein, IL6RQ Protein, gp80 Protein, IL-6R Protein, Il6r Protein, interleukin 6 receptor Protein, interleukin 6 receptor, alpha Protein, Il6r Protein, IL6R Protein, Il6ra Protein
- Hintergrund
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Background: Interleukin 6 receptor (IL-6R) also known as CD126 (Cluster of Differentiation 126) is a type I cytokine receptor. The low concentration of a soluble form of IL-6 receptor (sIL-6R) acts as an agonist of IL-6 activity. In the IL-6R/CD126/IL6R system, both a membrane-bound IL-6R and a sIL-6R protein are able to mediate IL-6 signals into the cells through the interaction of gp130. The resulting IL-6/sIL-6R protein complex is also capable of binding to gp130 and inducing intracellular signalling. Through this so-called 'trans-signalling' mechanism, IL-6 is able to stimulate cells that lack an endogenous mIL-6R. High levels of IL-6 and sIL-6R have been reported in several chronic inflammatory and autoimmune diseases as well as in cancer.Immune Checkpoint Immunotherapy Cancer Immunotherapy Targeted Therapy
Synonym: Il6ra;IL-6R
- Molekulargewicht
- 64.8 kDa
- NCBI Accession
- NP_058716
- Pathways
- JAK-STAT Signalweg, Autophagie, Growth Factor Binding, Cancer Immune Checkpoints
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