JAM2 Protein (Fc Tag)
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- Target Alle JAM2 Proteine anzeigen
- JAM2 (Junctional Adhesion Molecule 2 (JAM2))
- Protein-Typ
- Recombinant
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Spezies
- Ratte
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Quelle
- HEK-293 Cells
- Aufreinigungstag / Konjugat
- Dieses JAM2 Protein ist gelabelt mit Fc Tag.
- Verwendungszweck
- Recombinant Rat JAM-B/CD322 Protein (Fc Tag)
- Sequenz
- Met1-Asn236
- Produktmerkmale
- A DNA sequence encoding the rat JAM2 (Q3MHC0) (Met1-Asn236) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
- Reinheit
- > 90 % as determined by SDS-PAGE
- Endotoxin-Niveau
- < 1.0 EU per μg of the protein as determined by the LAL method
- Top Product
- Discover our top product JAM2 Protein
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- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Rekonstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from sterile PBS, pH 7.4
- Lagerung
- 4 °C,-20 °C,-80 °C
- Informationen zur Lagerung
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Target
- JAM2 (Junctional Adhesion Molecule 2 (JAM2))
- Andere Bezeichnung
- JAM-B/CD322 (JAM2 Produkte)
- Synonyme
- JAM2 Protein, cd322 Protein, jam-b Protein, jamb Protein, pro245 Protein, ve-jam Protein, vejam Protein, jam2 Protein, sb:cb1002 Protein, im:7155552 Protein, sc:d0813 Protein, si:ch211-160b11.5 Protein, LOC100227766 Protein, 1110002N23Rik Protein, 2410030G21Rik Protein, 2410167M24Rik Protein, JAM-2 Protein, JAM-B Protein, Jcam2 Protein, VE-JAM Protein, C21orf43 Protein, CD322 Protein, JAMB Protein, PRO245 Protein, VEJAM Protein, junctional adhesion molecule 2 Protein, junctional adhesion molecule 2a Protein, junctional adhesion molecule 2b Protein, junction adhesion molecule 2 Protein, JAM2 Protein, jam2 Protein, jam2a Protein, jam2b Protein, Jam2 Protein
- Hintergrund
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Background: Junctional adhesion molecule B (JAM-B), also known as Junctional adhesion molecule 2 (JAM2), Vascular endothelial junction-associated molecule (VE-JAM), and CD322, is a single-pass type I membrane protein which belongs to the immunoglobulin superfamily. It is prominently expressed on high endothelial venules. expression to be restricted to the high endothelial venule of tonsil and lymph nodes. The localization to the endothelium of arterioles in and around inflammatory and tumor foci. JAM-B can function as an adhesive ligand for the T cell line J45 and can interact with GM-CSF/IL-4-derived peripheral blood dendritic cells, circulating CD56(+) NK cells, circulating CD56(+)CD3(+) NK/T cells, and circulating CD56(+)CD3(+)CD8(+) cytolytic T cells. JAM-2 is expressed on high endothelial venules (HEVs) in human tonsil and on a subset of human leukocytes, suggesting that JAM-2 plays a central role in the regulation of transendothelial migration. It binds to very late activation antigen (VLA)-4, a leucocyte integrin that contributes to rolling and firm adhesion of lymphocytes to endothelial cells through binding to vascular cell adhesion molecule (VCAM)-1. JAM-B appears to contribute to leucocyte extravasation by facilitating not only transmigration but also rolling and adhesion. JAM-B acts as an adhesive ligand for interacting with a variety of immune cell types and may play a role in lymphocyte homing to secondary lymphoid organs.
Synonym: JAM2,JAM-2
- Molekulargewicht
- 50.3 kDa
- UniProt
- Q3MHC0
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