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KEAP1 Protein

KEAP1 Spezies: Human Wirt: Baculovirus infected Insect Cells Recombinant > 90 % as determined by reducing SDS-PAGE.
Produktnummer ABIN7317443
  • Target Alle KEAP1 Proteine anzeigen
    KEAP1 (Kelch-Like ECH-Associated Protein 1 (KEAP1))
    Protein-Typ
    Recombinant
    Spezies
    • 8
    • 2
    • 2
    Human
    Quelle
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    Baculovirus infected Insect Cells
    Verwendungszweck
    Recombinant Human KEAP1/INRF2 Protein
    Sequenz
    Gln2-Cys624
    Produktmerkmale
    A DNA sequence encoding the human KEAP1 (Q14145) (Gln2-Cys624) was expressed and purified with two additional amino acids (Gly & Pro ) at the N-terminus.
    Reinheit
    > 90 % as determined by reducing SDS-PAGE.
    Endotoxin-Niveau
    < 1.0 EU per μg as determined by the LAL method.
    Top Product
    Discover our top product KEAP1 Protein
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Please refer to the printed manual for detailed information.
    Buffer
    Lyophilized from sterile 20 mM Tris, 500 mM NaCl, 3 mM DTT, 10 % glycerol, pH 7.4
    Lagerung
    4 °C,-20 °C,-80 °C
    Informationen zur Lagerung
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Target
    KEAP1 (Kelch-Like ECH-Associated Protein 1 (KEAP1))
    Andere Bezeichnung
    KEAP1/INRF2 (KEAP1 Produkte)
    Synonyme
    INrf2 Protein, KLHL19 Protein, INRF2 Protein, mKIAA0132 Protein, Inrf2 Protein, fb36f11 Protein, keap1 Protein, wu:fb36f11 Protein, KEAP1 Protein, klhl19 Protein, zgc:171654 Protein, kelch like ECH associated protein 1 Protein, kelch-like ECH-associated protein 1 Protein, Kelch-like ECH-associated protein 1 Protein, kelch-like ECH-associated protein 1a Protein, kelch like ECH associated protein 1 L homeolog Protein, kelch-like ECH-associated protein 1b Protein, KEAP1 Protein, Keap1 Protein, keap1a Protein, keap1 Protein, keap1.L Protein, keap1b Protein
    Hintergrund

    Background: Kelch-like ECH-associated protein 1, also known as cytosolic inhibitor of Nrf2, Kelch-like protein 19, KEAP1 and INRF2, is a cytoplasm and nucleus protein which contains one BACK (BTB/Kelch associated) domain, one BTB (POZ) domain and six Kelch repeats. KEAP1 / INRF2 is broadly expressed, with highest levels in skeletal muscle. KEAP1 / INRF2 is a key regulator of the NRF2 transcription factor, which transactivates the antioxidant response element (ARE) and upregulates numerous proteins involved in antioxidant defense. Under basal conditions, KEAP1 / INRF2 targets NRF2 for ubiquitination and proteolytic degradation and as such is responsible for the rapid turnover of NRF2. KEAP1 / INRF2 retains NFE2L2 / NRF2 in the cytosol. KEAP1 / INRF2 functions as substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1. It targets NFE2L2 / NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. KEAP1 / INRF2 may also retain BPTF in the cytosol. It targets PGAM5 for ubiquitination and degradation by the proteasome.

    Synonym: INRF2,KEAP-1,KLHL19

    Molekulargewicht
    69.7 kDa
    UniProt
    Q14145
    Pathways
    Maintenance of Protein Location
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