METAP1 Protein

Produktnummer ABIN7319523

Produktdetails

Target: METAP1 (Methionyl Aminopeptidase 1 (METAP1))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Escherichia coli (E. coli)

Verwendungszweck: Recombinant Human METAP1 Protein

Sequenz: Met1-Phe386

Produktmerkmale: Recombinant Human METAP1 is produced by our E.coli expression system and the target gene encoding Met1-Phe386 is expressed.

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Frozen, Liquid

Buffer: Supplied as a 0.2 μm filtered solution of 20 mM Tris,500 mM NaCl,10 % glycerol, pH 8.0.

Lagerung: -20 °C

Informationen zur Lagerung: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Antigendetails

Target: METAP1 (Methionyl Aminopeptidase 1 (METAP1))

Andere Bezeichnung: METAP1 (METAP1 Produkte)

Hintergrund:

Background: Methionine Aminopeptidase 1 is a member of the M24 family of metalloproteases. METAP1 plays an important role in G(2)/M phase regulation of the cell cycle and may serve as a promising target for the discovery and development of new anticancer agents. METAP1 and METAP2 have different substrate specificity due to the differences in both size and shape of the active sites. The proteolytic removal of N-terminal methionine from nascent peptides is catalyzed by a family of enzymes known as methionine aminopeptidases (MetAPs) and is essential for cell growth. Inhibition of METAPs provides a novel strategy in developing anti-cancer drugs.

Synonym: Methionine aminopeptidase 1, MAP 1, MetAP 1, Peptidase M 1, METAP1,MAP1A,MetAP1A

Molekulargewicht: 43.2 kDa

UniProt: P53582

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling