Myelin Protein (His tag)
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- Target Alle Myelin Produkte
- Myelin
- Protein-Typ
- Recombinant
- Spezies
- Human
- Quelle
- Human Cells
- Aufreinigungstag / Konjugat
- Dieses Myelin Protein ist gelabelt mit His tag.
- Verwendungszweck
- Recombinant Human Myelin Protein P0/MPZ Protein (His Tag)
- Sequenz
- Ile30-Arg153
- Produktmerkmale
- Recombinant Human Myelin Protein P0 is produced by our Mammalian expression system and the target gene encoding Ile30-Arg153 is expressed with a 6His tag at the C-terminus.
- Reinheit
- > 95 % as determined by reducing SDS-PAGE.
- Endotoxin-Niveau
- < 1.0 EU per μg as determined by the LAL method.
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- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Rekonstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from a 0.2 μm filtered solution of 20 mM PB,150 mM NaCl, pH 7.2.
- Lagerung
- 4 °C,-20 °C,-80 °C
- Informationen zur Lagerung
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Target
- Myelin
- Abstract
- Myelin Produkte
- Hintergrund
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Background: Myelin Protein P0 (MPZ) is a single-pass type I membrane glycoprotein which belongs to the myelin P0 protein family. MPZ contains one Ig-like V-type (immunoglobulin-like) domain, absent in the central nervous system. MPZ is a major component of the myelin sheath in peripheral nerves. It is postulated that MPZ is a structural element in the formation and stabilisation of peripheral nerve myelin, holding its characteristic coil structure together by the interaction of its positively-charged domain with acidic lipids in the cytoplasmic face of the opposed bilayer, and by interaction between hydrophobic globular of adjacent extracellular domains. Defects in MPZ associated with Charcot-Marie-Tooth disease and Dejerine-Sottas disease.
Synonym: Myelin Protein P0, Myelin Peripheral Protein, MPP, Myelin Protein Zero, MPZ
- Molekulargewicht
- 15.2 kDa
- UniProt
- P25189
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