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Myeloperoxidase Protein (MPO) (His tag)

MPO Spezies: Maus Wirt: Human Cells Recombinant > 90 % as determined by reducing SDS-PAGE.
Produktnummer ABIN7320799
  • Target Alle Myeloperoxidase (MPO) Proteine anzeigen
    Myeloperoxidase (MPO)
    Protein-Typ
    Recombinant
    Spezies
    • 10
    • 4
    • 3
    • 2
    • 2
    • 2
    Maus
    Quelle
    • 12
    • 3
    • 2
    • 1
    • 1
    Human Cells
    Aufreinigungstag / Konjugat
    Dieses Myeloperoxidase Protein ist gelabelt mit His tag.
    Verwendungszweck
    Recombinant Mouse Myeloperoxidase/MPO Protein (His Tag)
    Sequenz
    Met16-Thr718
    Produktmerkmale
    Recombinant Mouse Myeloperoxidase is produced by our Mammalian expression system and the target gene encoding Met16-Thr718 is expressed with a 10His tag at the C-terminus.
    Reinheit
    > 90 % as determined by reducing SDS-PAGE.
    Endotoxin-Niveau
    < 1.0 EU per μg as determined by the LAL method.
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Please refer to the printed manual for detailed information.
    Buffer
    Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
    Lagerung
    4 °C,-20 °C,-80 °C
    Informationen zur Lagerung
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Target
    Myeloperoxidase (MPO)
    Andere Bezeichnung
    Myeloperoxidase/MPO (MPO Produkte)
    Synonyme
    mKIAA4033 Protein, MPO Protein, LOC100335032 Protein, POX2' Protein, XPOX2' Protein, mpo Protein, mpo-A Protein, pmr-1 Protein, pmr1 Protein, pox2 Protein, xpox2 Protein, myeloperoxidase Protein, myeloperoxidase L homeolog Protein, MPO Protein, Mpo Protein, LOC100335032 Protein, mpo.L Protein
    Hintergrund

    Background: Myeloperoxidase (MPO) is a hemecontaining enzyme belonging to the XPO subfamily of peroxidases. It is an abundant neutrophil and monocyte glycoprotein that catalyzes the hydrogen peroxidedependent conversion of chloride, bromide, and iodide to multiple reactive species. MPO activity results in protein nitrosylation and the formation of 3-chlorotyrosine and dityrosine crosslinks. Modification of ApoB100, as well as the lipid and cholesterol components of LDL and HDL, promotes the development of atherosclerosis. MPO is also associated with a variety of other diseases, and inhibits vasodilation in inflammation by depleting the levels of NO. Serum albumin functions as a carrier protein during MPO movement to the basolateral side of epithelial cells. MPO is stored in neutrophil azurophilic granules. Upon cellular activation, it is deposited into pathogencontaining phagosomes. While mice lacking MPO are impaired in clearing select microbial infections,MPO deficiency in humans does not necessarily result in heightened susceptibility to infections.

    Synonym: Myeloperoxidase, MPO

    Molekulargewicht
    81.1 kDa
    UniProt
    P11247
    Pathways
    Chromatin Binding
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