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MYOC Protein (His tag)

MYOC Spezies: Human Wirt: HEK-293 Cells Recombinant > 95 % as determined by reducing SDS-PAGE.
Produktnummer ABIN7197075
  • Target Alle MYOC Proteine anzeigen
    MYOC (Myocilin (MYOC))
    Protein-Typ
    Recombinant
    Spezies
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Quelle
    • 6
    • 2
    • 2
    • 1
    HEK-293 Cells
    Aufreinigungstag / Konjugat
    Dieses MYOC Protein ist gelabelt mit His tag.
    Verwendungszweck
    Recombinant Human MYOC/Myocilin Protein (His Tag)
    Sequenz
    Met 1-Met 504
    Produktmerkmale
    A DNA sequence encoding the full length of human MYOC (Q99972) (Met 1-Met 504) was fused with a polyhistidine tag at the C-terminus.
    Reinheit
    > 95 % as determined by reducing SDS-PAGE.
    Endotoxin-Niveau
    < 1.0 EU per μg as determined by the LAL method.
    Top Product
    Discover our top product MYOC Protein
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Please refer to the printed manual for detailed information.
    Buffer
    Lyophilized from sterile PBS, pH 7.4
    Lagerung
    4 °C,-20 °C,-80 °C
    Informationen zur Lagerung
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Target
    MYOC (Myocilin (MYOC))
    Andere Bezeichnung
    MYOC/Myocilin (MYOC Produkte)
    Synonyme
    MYOC Protein, MGC136645 Protein, zgc:136645 Protein, AI957332 Protein, GLC1A Protein, TIGR Protein, GPOA Protein, JOAG Protein, JOAG1 Protein, myocilin Protein, Tigr Protein, myocilin Protein, MYOC Protein, myoc Protein, Myoc Protein
    Hintergrund

    Background: Myocilin, also known as Trabecular meshwork-induced glucocorticoid response protein, MYOC and GLC1A, is a protein which contains one olfactomedin-like domain. Myocilin / MYOC may participate in the obstruction of fluid outflow in the trabecular meshwork. Myocilin / MYOC is expressed in large amounts in various types of muscle, ciliary body, papillary sphincter, skeletal muscle, heart and other tissues. Myocilin / MYOC is expressed predominantly in the retina. In normal eyes, it is found in the inner uveal meshwork region and the anterior portion of the meshwork. In contrast, in many glaucomatous eyes, it is found in more regions of the meshwork and appeared more intensively than in normal eyes, regardless of the type or clinical severity of glaucoma. Defects in Myocilin / MYOC may contribute to primary congenital glaucoma type 3A (GLC3A). Defects in MYOC may also contribute to this phenotype via digenic inheritance. GLC3A is an autosomal recessive form of primary congenital glaucoma (PCG). PCG is characterized by marked increase of intraocular pressure at birth or early choldhood, large ocular globes (buphthalmos) and corneal edema.

    Synonym: GLC1A;GPOA;JOAG;JOAG1;myocilin;TIGR

    Molekulargewicht
    54.7 kDa
    UniProt
    Q99972
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