NFASC Protein (His tag)

Produktnummer ABIN7317169

Produktdetails

Target: NFASC (Neurofascin (NFASC))

Protein-Typ: Recombinant

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses NFASC Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human NFASC/Neurofascin protein (His Tag)

Sequenz: Met 1-Gln939

Produktmerkmale: A DNA sequence encoding the human NFASC (O94856-12) (Met1-Gln939) was expressed with a C-terminal polyhistidine tag.

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: NFASC (Neurofascin (NFASC))

Andere Bezeichnung: NFASC/Neurofascin (NFASC Produkte)

Hintergrund:

Background: NFASC, also known as neurofascin, belongs to the immunoglobulin superfamily, L1/neurofascin/NgCAM family. It contains 5 fibronectin type-III domains and 6 Ig-like C2-type (immunoglobulin-like) domains. NFASC functions in neurite outgrowth, neurite fasciculation, and organization of the axon initial segment (AIS) and nodes of Ranvier on axons during early development. Both the AIS and nodes of Ranvier contain high densities of voltage-gated Na+ (Nav) channels which are clustered by interactions with cytoskeletal and scaffolding proteins including this protein, gliomedin, ankyrin 3 (ankyrin-G), and betaIV spectrin. NFASC links the AIS extracellular matrix to the intracellular cytoskeleton.

Synonym: NF,NRCAML

Molekulargewicht: 104.4 kDa

Pathways: Cell-Cell Junction Organization