NRP2 Protein (Fc Tag)
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- Target Alle NRP2 Proteine anzeigen
- NRP2 (Neuropilin 2 (NRP2))
- Protein-Typ
- Recombinant
- Biologische Aktivität
- Active
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Spezies
- Human
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Quelle
- HEK-293 Cells
- Aufreinigungstag / Konjugat
- Dieses NRP2 Protein ist gelabelt mit Fc Tag.
- Verwendungszweck
- Recombinant Human Neuropilin-2/NRP2 Protein (Fc Tag)(Active)
- Sequenz
- Met 1-Tyr855
- Produktmerkmale
- A DNA sequence encoding the human NRP2 (NP_003863.2)(Met1-Tyr855) was expressed with the Fc region of human IgG1 at the C-terminus.
- Reinheit
- > 95 % as determined by reducing SDS-PAGE.
- Endotoxin-Niveau
- < 1.0 EU per μg as determined by the LAL method.
- Biological Activity Comment
- Measured by its binding ability in a functional ELISA.2.Immobilized human VEGFC-His at 10μg/mL (100μL/well) can bind human NRP2-Fc, the EC50 of human NRP2-Fc is 0.1-0.5μg/mL.
- Top Product
- Discover our top product NRP2 Protein
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- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Rekonstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from sterile PBS, pH 7.4
- Lagerung
- 4 °C,-20 °C,-80 °C
- Informationen zur Lagerung
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Target
- NRP2 (Neuropilin 2 (NRP2))
- Andere Bezeichnung
- Neuropilin-2/NRP2 (NRP2 Produkte)
- Synonyme
- NP2 Protein, NPN2 Protein, PRO2714 Protein, VEGF165R2 Protein, 1110048P06Rik Protein, Np-2 Protein, Np2 Protein, Npn-2 Protein, Npn2 Protein, neuropilin-2 Protein, neuropilin 2 Protein, NRP2 Protein, Nrp2 Protein
- Hintergrund
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Background: Neuropilin-2 (NRP-2) which is related to NRP-1, is a type I? transmembrane glycoprotein and has the structure characteristic with five main extracellular domains: two complement binding (CUB) domains, two coagulation factor V/VIII homology domains, and a MAM (meprin, tyrosine phosphatase domain) region. NRP-2 is a receptor capable of binding two disparate ligands, classIII semaphorins (SEMA) and vascular endothelial growth factors (VEGF), and thus regulates two diverse systems by activating cellular signaling pathways via interacting with other cell surface receptors such as VEGF receptors and plexins. NRP-2 is well known for its role in facilitating axonal guidance during the development of the neuronal system, and additionally, it is also expressed in vascular endothelial cells and lymphatic endothelium where it affects proliferation, migration, angiogenesis, as well as formation of small lymphatic vessels and capillaries. Recent study has identified NRP-2 as a polysialylated protein expressed in human dendritic cells and modulates DC-T cell Interactions. Nearly all tumor cells express neuropilins and NRP-2 is predominantly expressed in neuronal tumors and melanomas. Furthermore, it is suggested that as the specific ligand for NRP-2, SEMA 3F inhibits tumor angiogenesis and metastasis.
Synonym: Neuropilin-2,NP2,NPN2,PRO2714,VEGF165R2
- Molekulargewicht
- 120.7 kDa
- NCBI Accession
- NP_003863
- Pathways
- Signaling Events mediated by VEGFR1 and VEGFR2, VEGFR1 Specific Signals
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