Oncostatin M Receptor Protein (OSMR) (AA 1-740) (His tag)

Produktnummer ABIN7317608

Produktdetails

Target: Oncostatin M Receptor (OSMR)

Protein-Typ: Recombinant

Proteineigenschaft: AA 1-740

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses Oncostatin M Receptor Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human OSMR/IL31RB Protein (aa 1-740, His Tag)

Sequenz: Met 1-Met 740

Produktmerkmale: A DNA sequence encoding the human OSMR (NP_003990.1) extracellular domain (Met 1-Met 740) was expressed, fused with a polyhistidine tag at the C-terminus.

Reinheit: > 96 % as determined by reducing SDS-PAGE.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: Oncostatin M Receptor (OSMR)

Andere Bezeichnung: OSMR/IL31RB (OSMR Produkte)

Synonyme: OSMRB Protein, PLCA1 Protein, oncostatin M receptor Protein, OSMR Protein, Osmr Protein

Hintergrund:

Background: Oncostatin-M specific receptor subunit beta also known as the oncostatin M receptor (OSMR) and Interleukin-31 receptor subunit beta (IL-31RB), is one of the receptor proteins for oncostatin M. OSMR is a member of the type I cytokine receptor family. IL-31RB/OSMR heterodimerizes with interleukin 6 signal transducer to form the type II oncostatin M receptor and with interleukin 31 receptor A to form the interleukin 31 receptor, and thus transduces oncostatin M and interleukin 31 induced signaling events. Mutations in IL-31RB/OSMR have been associated with familial primary localized cutaneous amyloidosis. Defects in IL-31RB/OSMR are the cause of amyloidosis primary localized cutaneous type 1 (PLCA1), also known as familial lichen amyloidosis or familial cutaneous lichen amyloidosis. PLCA1 is a hereditary primary amyloidosis characterized by localized cutaneous amyloid deposition. This condition usually presents with itching (especially on the lower legs) and visible changes of skin hyperpigmentation and thickening (lichenification) that may be exacerbated by chronic scratching and rubbing. The amyloid deposits probably reflect a combination of degenerate keratin filaments, serum amyloid P component, and deposition of immunoglobulins.

Synonym: Oncostatin-M-Specific Receptor Subunit Beta, Interleukin-31 Receptor Subunit Beta, IL-31 Receptor Subunit Beta, IL-31R Subunit Beta, IL-31R-Beta, IL-31RB, OSMR,OSMRB,PLCA1

Molekulargewicht: 82.6 kDa

NCBI Accession: NP_003990

Pathways: JAK-STAT Signalweg, Growth Factor Binding