Osteomodulin Protein (OMD) (His tag)
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- Target Alle Osteomodulin (OMD) Proteine anzeigen
- Osteomodulin (OMD)
- Protein-Typ
- Recombinant
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Spezies
- Maus
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Quelle
- HEK-293 Cells
- Aufreinigungstag / Konjugat
- Dieses Osteomodulin Protein ist gelabelt mit His tag.
- Verwendungszweck
- Recombinant Mouse Osteomodulin/OMD Protein (His Tag)
- Sequenz
- Met 1-Ile 423
- Produktmerkmale
- A DNA sequence encoding the mouse OMD (NP_036180.1) (Met 1-Ile 423) precusor was expressed, with a C-terminal polyhistidine tag.
- Reinheit
- > 96 % as determined by SDS-PAGE
- Endotoxin-Niveau
- < 1.0 EU per μg of the protein as determined by the LAL method.
- Top Product
- Discover our top product OMD Protein
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- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Rekonstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from sterile PBS, pH 7.4
- Lagerung
- 4 °C,-20 °C,-80 °C
- Informationen zur Lagerung
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Target
- Osteomodulin (OMD)
- Andere Bezeichnung
- Osteomodulin/OMD (OMD Produkte)
- Synonyme
- si:ch211-103f16.5 Protein, OMD Protein, OSAD Protein, SLRR2C Protein, osteomodulin Protein, omd Protein, OMD Protein, Omd Protein
- Hintergrund
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Background: Osteomodulin (OMD), also known as Osteoadherin (OSAD), Keratan sulfate proteoglycan osteomodulin, KSPG osteomodulin, and SLRR2C, is a secreted protein which belongs to the small leucine-rich proteoglycan (SLRP) family and Class II subfamily. SLRP family proteins are normally found in extracellular matrices, but Osteomodulin is the only member restricted to mineralized tissues. Osteomodulin is primarily expressed by osteoblasts and might have a role in regulation of mineralization. In bone OSAD has been localized in primary spongiosa within the bovine fetal rib growth plate. Moreover, in situ hybridization has shown expression of OSAD in osteoblasts close to the cartilage and bone border in the growth plate of rat femur. OSAD may play an important role during tooth development and biomineralization of dentin. Osteomodulin is a cell binding keratan sulfate proteoglycan which was recently isolated from mineralized bovine bone and subsequently cloned and sequenced. Osteomodulin may be implicated in biomineralization processes. It has a function in binding of osteoblasts via the alpha (V) beta (3)-integrin. It is likely that Osteomodulin is an osteoblast maturation marker that is induced by osteoclast activity. Osteomodulin is also an early marker for terminally differentiated matrix producing osteoblasts.
Synonym: OSAD,SLRR2C
- Molekulargewicht
- 48.8 kDa
- NCBI Accession
- NP_036180
- Pathways
- Glycosaminoglycan Metabolic Process
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