OSTM1 Protein (His tag)
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- Target Alle OSTM1 Proteine anzeigen
- OSTM1 (Osteopetrosis Associated Transmembrane Protein 1 (OSTM1))
- Protein-Typ
- Recombinant
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Spezies
- Human
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Quelle
- HEK-293 Cells
- Aufreinigungstag / Konjugat
- Dieses OSTM1 Protein ist gelabelt mit His tag.
- Verwendungszweck
- Recombinant Human OSTM1 Protein (His Tag)
- Sequenz
- Met 1-Pro 284
- Produktmerkmale
- A DNA sequence encoding the extracellular domain of human OSTM1 (NP_054747.2) (Met 1-Pro 284) was expressed, fused with a C-terminal polyhistidine tag.
- Reinheit
- > 97 % as determined by reducing SDS-PAGE.
- Endotoxin-Niveau
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product OSTM1 Protein
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- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Rekonstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from sterile PBS, pH 7.4
- Lagerung
- 4 °C,-20 °C,-80 °C
- Informationen zur Lagerung
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Target
- OSTM1 (Osteopetrosis Associated Transmembrane Protein 1 (OSTM1))
- Andere Bezeichnung
- OSTM1 (OSTM1 Produkte)
- Synonyme
- MGC145644 Protein, si:ch73-257c13.3 Protein, GIPN Protein, GL Protein, OPTB5 Protein, 1200002H13Rik Protein, HSPC019 Protein, gl Protein, Gipn Protein, OSTM1 Protein, osteopetrosis associated transmembrane protein 1 Protein, OSTM1 Protein, ostm1 Protein, Ostm1 Protein
- Hintergrund
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Background: Osteopetrosis-associated transmembrane protein 1 (OSTM1) is a Single-pass type I membrane protein. It is expressed in many hematopoietic cells of the myeloid and lymphoid B- and T-lineages. The analysis of OSTM1 association with CLCN7 demonstrated that OSTM1 requires CLCN7 to localize to lysosomes, whereas the formation of a CLCN7-OSTM1 complex is required to stabilize CLCN7. The researches found that OSTM1 plays a major role in myelopoiesis and lymphopoiesis and provided evidence of a crosstalk mechanism between hematopoietic cells for osteoclast activation. Thus, OSTM1 has a important role in osteoclast function and activation. The loss of function of OSTM1 results in deregulation of multiple hematopoietic lineages in addition to osteoclast lineage, OSTM1-defect patients display the most severe recessive osteopetrotic phenotype and die at early ages. Furthermore, it is suggested that OSTM1 has a primary role in neural development not related to lysosomal dysfunction. The canonical Wnt/beta-catenin signaling pathway may be a molecular basis for OSTM1 mutations and severe autosomal recessive osteopetrosis (ARO).
Synonym: GIPN;GL;HSPC019;OPTB5
- Molekulargewicht
- 29.7 kDa
- NCBI Accession
- NP_054747
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