PAPPA2 Protein (His tag)
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- Target Alle PAPPA2 Proteine anzeigen
- PAPPA2 (Pappalysin 2 (PAPPA2))
- Protein-Typ
- Recombinant
- Spezies
- Human
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Quelle
- HEK-293 Cells
- Aufreinigungstag / Konjugat
- Dieses PAPPA2 Protein ist gelabelt mit His tag.
- Verwendungszweck
- Recombinant Human PAPPA2/Pappalysin 2 Protein (His Tag)
- Sequenz
- Ser 234-Cys 1396
- Produktmerkmale
- A DNA sequence encoding the human PAPPA2 mature form (NP_064714.2) corresponding to amino acid (Ser 234-Cys 1396) was expressed, with a carboxy-terminal polyhistidine tag.
- Reinheit
- > 90 % as determined by reducing SDS-PAGE.
- Endotoxin-Niveau
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product PAPPA2 Protein
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- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Rekonstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from sterile PBS, pH 7.4
- Lagerung
- 4 °C,-20 °C,-80 °C
- Informationen zur Lagerung
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Target
- PAPPA2 (Pappalysin 2 (PAPPA2))
- Andere Bezeichnung
- PAPPA2/Pappalysin 2 (PAPPA2 Produkte)
- Synonyme
- PAPP-A2 Protein, PLAC3 Protein, Pappe Protein, PAPP-E Protein, PAPPE Protein, si:dkey-39f8.1 Protein, pappalysin 2 Protein, Pappa2 Protein, PAPPA2 Protein, pappa2 Protein
- Hintergrund
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Background: Pappalysin-2/PAPP-A2 is the second member of the pappalysin family of metzincin superfamily, of which PAPP-A is the first member. There is no homology between the prepro-peptides of PAPP-A and PAPP-A2, but 46 % of the residues of mature PAPP-A are also present in mature PAPP-A2. PAPP-A specifically cleaves insulin-like growth factor-binding protein(IGFBP)-4, one of six known modulators of IGF-I and -II, whereas PAPP-A2 specifically cleaved IGFBP-5 at one site, between Ser-143 and Lys-144. In contrast to the cleavage of IGFBP-4 by PAPP-A that strictly requires the presence of IGF, the cleavage of IGFBP-5 by PAPP-A2 was IGF-independent. Recent data firmly establish PAPP-A and IGFBP-4 as an important functional pair in several systems. Because of its close relationship with PAPP-A, both structurally and functionally, PAPP-A2 is a likely candidate for IGFBP-5 proteinase in many tissues and conditioned media where IGFBP-5 proteolysis has been reported.
Synonym: PAPP-A2,PAPP-E,PAPPE,PLAC3
- Molekulargewicht
- 131 kDa
- NCBI Accession
- NP_064714
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