Peroxiredoxin 1 Protein (PRDX1) (His tag)

Produktnummer ABIN7320235

Produktdetails

Target: Peroxiredoxin 1 (PRDX1)

Protein-Typ: Recombinant

Spezies: Maus

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses Peroxiredoxin 1 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Mouse Peroxiredoxin 1/PRDX1 Protein (His Tag)

Sequenz: Met 1-Lys 199

Produktmerkmale: A DNA sequence encoding the mouse PRDX1 (P35700) (Met 1-Lys 199) was expressed, with a C-terminal polyhistidine tag.

Reinheit: > 85 % as determined by SDS-PAGE

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, 10 % glycerol, pH 7.4

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: Peroxiredoxin 1 (PRDX1)

Andere Bezeichnung: Peroxiredoxin 1/PRDX1 (PRDX1 Produkte)

Hintergrund:

Background: Peroxiredoxin-1, also known as Thioredoxin peroxidase 2, Natural killer cell-enhancing factor A, PRDX1, and PAGA, is a member of the ahpC/TSA family. Peroxiredoxin-1 is constitutively expressed in most human cells. It is induced to higher levels upon serum stimulation in untransformed and transformed cells. Peroxiredoxins (PRDXs) are a family of antioxidant enzymes that are also known as scavengers of peroxide in mammalian cells. The overexpression of Peroxiredoxin-1, which is one of the peroxiredoxins that is a ubiquitously expressed protein, was related to a poor prognosis in several types of human cancers. Peroxiredoxin-1 is involved in redox regulation of the cell. It reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin and may play an important role in eliminating peroxides generated during metabolism. Peroxiredoxin-1 Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H2O2. The reduced Peroxiredoxin-1 expression is an important factor in esophageal squamous cancer progression and could serve as a useful prognostic marker.

Synonym: MSP23,NkefA,OSF-3,OSF3,PAG,Paga,PrdxI,prx1,PrxI,Tdpx2,TDX2,TPxA

Molekulargewicht: 23.5 kDa

UniProt: P35700

Pathways: p53 Signalweg, EGFR Signaling Pathway, CXCR4-mediated Signaling Events