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PDE9A Protein (His tag)

PDE9A Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant > 95 % as determined by reducing SDS-PAGE.
Produktnummer ABIN7317497
  • Target Alle PDE9A Proteine anzeigen
    PDE9A (phosphodiesterase 9A (PDE9A))
    Protein-Typ
    Recombinant
    Spezies
    • 9
    • 2
    • 1
    Human
    Quelle
    • 3
    • 2
    • 2
    • 2
    • 1
    Escherichia coli (E. coli)
    Aufreinigungstag / Konjugat
    Dieses PDE9A Protein ist gelabelt mit His tag.
    Verwendungszweck
    Recombinant Human PDE9A Protein (His Tag)
    Sequenz
    Pro 181-Lys 506
    Produktmerkmale
    A DNA sequence encoding the human PDE9A (O76083-2) C-terminal segment (Pro 181-Lys 506) was expressed, with a polyhistide tag at the N-terminus.
    Reinheit
    > 95 % as determined by reducing SDS-PAGE.
    Top Product
    Discover our top product PDE9A Protein
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Please refer to the printed manual for detailed information.
    Buffer
    Lyophilized from sterile PBS, pH 7.4
    Lagerung
    4 °C,-20 °C,-80 °C
    Informationen zur Lagerung
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Target
    PDE9A (phosphodiesterase 9A (PDE9A))
    Andere Bezeichnung
    PDE9A (PDE9A Produkte)
    Synonyme
    PDE9A Protein, MGC116558 Protein, Pde9a Protein, HSPDE9A2 Protein, PDE9A1 Protein, phosphodiesterase 9A Protein, phosphodiesterase 9A S homeolog Protein, high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Protein, PDE9A Protein, pde9a.S Protein, Pde9a Protein, LOC100549810 Protein, pde9a Protein
    Hintergrund

    Background: High affinity cGMP-specific 3';5'-cyclic phosphodiesterase 9A; also known as PDE9A; is a member of the cyclic nucleotide phosphodiesterase family and PDE9 subfamily. PDE9A is expressed in all tissues examined (testis; brain; small intestine; skeletal muscle; heart; lung; thymus; spleen; placenta; kidney; liver; pancreas; ovary and prostate) except blood. Highest levels of PDE9A is in brain; heart; kidney; spleen; prostate and colon. Isoform PDE9A12 is found in prostate. PDE9A mRNA is widely distributed throughout the rat and mouse brain; with the highest expression observed in cerebellar Purkinje cells. PDE9A is the only cGMP-specific PDE with significant expression in the forebrain; and as such is likely to play an important role in NO-cGMP signaling. PDE9A is highly conserved between species and is widely distributed throughout the rodent brain. PDE9A is probably involved in maintenance of low cGMP levels in cells and might play an important role in a variety of brain functions involving cGMP-mediated signal transduction. PDE9A hydrolyzes the second messenger cGMP; which is a key regulator of many important physiological processes. PDE9A represents a novel drug target worthy of further study.

    Synonym: HSPDE9A2

    Molekulargewicht
    40 kDa
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