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PSPH Protein

PSPH Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant > 84 % as determined by reducing SDS-PAGE.
Produktnummer ABIN7317234
  • Target Alle PSPH Proteine anzeigen
    PSPH (Phosphoserine Phosphatase (PSPH))
    Protein-Typ
    Recombinant
    Spezies
    • 7
    • 1
    • 1
    • 1
    • 1
    Human
    Quelle
    • 3
    • 3
    • 2
    • 2
    • 1
    Escherichia coli (E. coli)
    Verwendungszweck
    Recombinant Human PSPH Protein
    Sequenz
    Met 1-Glu 225
    Produktmerkmale
    A DNA sequence encoding the human PSPH (P78330) (Met 1-Glu 225) was expressed and purified.
    Reinheit
    > 84 % as determined by reducing SDS-PAGE.
    Top Product
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  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Please refer to the printed manual for detailed information.
    Buffer
    Lyophilized from sterile PBS, pH 7.5
    Lagerung
    4 °C,-20 °C,-80 °C
    Informationen zur Lagerung
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Target
    PSPH (Phosphoserine Phosphatase (PSPH))
    Andere Bezeichnung
    PSPH (PSPH Produkte)
    Synonyme
    PSP Protein, PSPHD Protein, AI480570 Protein, PSPase Protein, PSPH Protein, psph Protein, MGC78828 Protein, zgc:112414 Protein, DDBDRAFT_0183847 Protein, DDBDRAFT_0230054 Protein, DDB_0183847 Protein, DDB_0230054 Protein, phosphoserine phosphatase Protein, phosphoserine phosphatase L homeolog Protein, PSP; O-phosphoserine phosphohydrolase; PSPase Protein, phosphoserine phosphatase SerB Protein, BPI fold containing family A member 2 Protein, PSPH Protein, Psph Protein, psph.L Protein, psph Protein, serB Protein, serB-1 Protein, LOC5568588 Protein, PSP Protein, Svir_29300 Protein, MMAH_RS03435 Protein, BPIFA2 Protein
    Hintergrund

    Background: Phosphoserine phosphatase (PSPH) belongs to a subfamily of the phosphotransferases. PSPH is the rate-limiting enzyme in l-serine biosynthesis. It has previously been found that Phosphoserine phosphatase (PSPH) plays a role in epidermal homeostasis. Phosphoserine phosphatase (PSP) catalyzes the hydrolysis of phosphoserine to serine. Phosphoserine phosphatase (PSPH) expression has been examined in human-mouse somatic cell hybrids retaining different combination of human chromosomes. Phosphoserine phosphatase (PSPH) is expressed throughout the proliferative layer of the epidermis and hair follicles in rodent and human skin and is highly induced in SCC. In keratinocytes, Phosphoserine phosphatase (PSPH) is a cytoplasmic protein that primarily localizes to endosomes and is present primarily as a homodimer. Knock down of Phosphoserine phosphatase (PSPH) dramatically diminished SCC cell proliferation and cyclin D1 levels in the presence of exogenous of l-serine production suggesting a non-canonical role for Phosphoserine phosphatase (PSPH) in epithelial carcinogenesis. Phosphoserine phosphatase (PSPH) is highly induced in proliferative normal keratinocytes and in skin tumors. Phosphoserine phosphatase (PSPH) appears to be critical for the proliferation of SCC cells, however, this phenomenon may not involve the phosphoserine metabolic pathway.

    Synonym: Phosphoserine Phosphatase, PSP, PSPase, L-3-Phosphoserine Phosphatase, O-Phosphoserine Phosphohydrolase, PSPH

    Molekulargewicht
    25 kDa
    UniProt
    P78330
    Pathways
    Warburg Effekt
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