PDGFRB Protein (His tag)
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- Target Alle PDGFRB Proteine anzeigen
- PDGFRB (Platelet Derived Growth Factor Receptor beta (PDGFRB))
- Protein-Typ
- Recombinant
- Biologische Aktivität
- Active
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Spezies
- Ratte
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Quelle
- HEK-293 Cells
- Aufreinigungstag / Konjugat
- Dieses PDGFRB Protein ist gelabelt mit His tag.
- Verwendungszweck
- Recombinant Rat PDGFRB/CD140b Protein (His Tag)(Active)
- Sequenz
- Met1-Lys530
- Produktmerkmale
- A DNA sequence encoding the rat PDGFRB (Q05030) (Met1-Lys530) was expressed, fused with a polyhistidine tag at the C-terminus.
- Reinheit
- > 95 % as determined by SDS-PAGE
- Endotoxin-Niveau
- < 1.0 EU per μg of the protein as determined by the LAL method
- Biological Activity Comment
- Measured by its binding ability in a functional ELISA. Immobilized rat PDGFRB-His at 10 μg/ml (100 μl/well) can bind Cynomolgus PDGFB , The EC50 of Cynomolgus PDGFB is 3-7 ng/ml.
- Top Product
- Discover our top product PDGFRB Protein
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- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Rekonstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from sterile PBS, pH 7.4
- Lagerung
- 4 °C,-20 °C,-80 °C
- Informationen zur Lagerung
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Target
- PDGFRB (Platelet Derived Growth Factor Receptor beta (PDGFRB))
- Andere Bezeichnung
- PDGFRB/CD140b (PDGFRB Produkte)
- Synonyme
- AI528809 Protein, CD140b Protein, PDGFR-1 Protein, Pdgfr Protein, CD140B Protein, IBGC4 Protein, JTK12 Protein, PDGFR Protein, PDGFR1 Protein, platelet derived growth factor receptor, beta polypeptide Protein, platelet derived growth factor receptor beta Protein, Pdgfrb Protein, PDGFRB Protein
- Hintergrund
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Background: The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. CD140b, also known as PDGFRB, is a member of the CD system. CD140b is a cell surface tyrosine kinase receptor essencial for development interacting with the platelet-derived growth factors (PDGFs) which serves as mitogens for mesenchymal cells. CD140b can bind with platelet-derived growth factor (PDGF)-B, that are secreted by tumors and phosphorylation of PDGFR-β was correlated with depth of cancer invasion at statistically significant level.Immune Checkpoint Immunotherapy Cancer Immunotherapy Targeted Therapy
Synonym: PDGFRB;Pdgfr;Pdgfr1;PDGFR-1
- Molekulargewicht
- 57.6 kDa
- UniProt
- Q05030
- Pathways
- Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Inositol Metabolic Process, Glycosaminoglycan Metabolic Process, Smooth Muscle Cell Migration, Platelet-derived growth Factor Receptor Signaling
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