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Pleiotrophin Protein (PTN)

PTN Spezies: Maus Wirt: Baculovirus infected Insect Cells Recombinant > 95 % as determined by SDS-PAGE Active
Produktnummer ABIN7197415
  • Target Alle Pleiotrophin (PTN) Proteine anzeigen
    Pleiotrophin (PTN)
    Protein-Typ
    Recombinant
    Biologische Aktivität
    Active
    Spezies
    • 8
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    Maus
    Quelle
    • 9
    • 5
    • 2
    • 2
    • 1
    • 1
    Baculovirus infected Insect Cells
    Verwendungszweck
    Recombinant Mouse Pleiotrophin/PTN/HB-GAM Protein (Active)
    Sequenz
    Met1-Asp168
    Produktmerkmale
    A DNA sequence encoding the mouse PTN (P63089) (Met1-Asp168) was expressed.
    Reinheit
    > 95 % as determined by SDS-PAGE
    Endotoxin-Niveau
    < 1.0 EU per μg of the protein as determined by the LAL method.
    Biological Activity Comment
    Measured by its binding ability in a functional ELISA. Immobilized mouse PTN at 10 μg/ml (100 μl/well) can bind rat SDC1-Fc , The EC50 of rat SDC1-Fc is 0.4-1.1 μg/ml.
    Top Product
    Discover our top product PTN Protein
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Please refer to the printed manual for detailed information.
    Buffer
    Lyophilized from sterile 20 mM Tris, 1M NaCl, pH 7.4
    Lagerung
    4 °C,-20 °C,-80 °C
    Informationen zur Lagerung
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Target
    Pleiotrophin (PTN)
    Andere Bezeichnung
    Pleiotrophin/PTN/HB-GAM (PTN Produkte)
    Synonyme
    zHBNF Protein, zgc:111787 Protein, harp Protein, hbnf Protein, X-PTF Protein, hbgf8 Protein, negf1 Protein, ptn Protein, PTN Protein, HARP Protein, HBGF8 Protein, HBNF Protein, NEGF1 Protein, PTN-A Protein, HB-GAM Protein, HBBM Protein, HBGF-8 Protein, OSF-1 Protein, HBBN Protein, OSF Protein, Osf-1 Protein, Osf1 Protein, Hbnf Protein, pleiotrophin Protein, pleiotrophin L homeolog Protein, ptn Protein, PTN Protein, ptn.L Protein, Ptn Protein
    Hintergrund

    Background: HB-GAM belongs to the pleiotrophin family. During embryonic and early postnatal development, HB-GAM is expressed in the central and peripheral nervous system and also in several non-neural tissues, notably lung, kidney, gut and bone. While in the adult central nervous system, it is expressed in an activity-dependent manner in the hippocampus where it can suppress long term potentiation induction. HB-GAM has a low expression in other areas of the adult brain, but it can be induced by ischemic insults, or targeted neuronal damaged in the entorhinal cortex or in the substantia nigra pars compacta. It is structurally related to midkine and retinoic acid induced heparin-binding protein and has a high affinity for heparin. HB-GAM binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti-apoptotic signaling of PTN and regulation of cell proliferation. It also functions as a secreted growth factor and induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells.

    Synonym: Pleiotrophin, PTN, Heparin-binding brain mitogen, HBBM, Heparin-binding growth factor 8, HBGF-8, Osteoblast-specific factor 1, OSF-1,HARP,HB-GAM,HBBN,HBNF,OSF,Osf-1,Osf1

    Molekulargewicht
    15.3 kDa
    UniProt
    P63089
    Pathways
    RTK Signalweg
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