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PRDM2 Protein

PRDM2 Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant > 96 % as determined by reducing SDS-PAGE.
Produktnummer ABIN7317619
  • Target Alle PRDM2 Proteine anzeigen
    PRDM2 (PR Domain Containing 2, with ZNF Domain (PRDM2))
    Protein-Typ
    Recombinant
    Spezies
    Human
    Quelle
    • 2
    • 1
    • 1
    Escherichia coli (E. coli)
    Verwendungszweck
    Recombinant Human PRDM2/RIZ1 Protein
    Sequenz
    Met 1-Ala 200
    Produktmerkmale
    A DNA sequence encoding the N-terminal segment of human PRDM2 (NP_036363.2) (Met 1-Ala 200), containing the SET domian, was expressed, with two additonal amino acids (Gly & Pro) at the N-terminus.
    Reinheit
    > 96 % as determined by reducing SDS-PAGE.
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  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Please refer to the printed manual for detailed information.
    Buffer
    Lyophilized from sterile 20 mM Tris, 150 mM NaCl, 0.5 mM DTT, 0.5 mM GSH, pH 8.0
    Lagerung
    4 °C,-20 °C,-80 °C
    Informationen zur Lagerung
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Target
    PRDM2 (PR Domain Containing 2, with ZNF Domain (PRDM2))
    Andere Bezeichnung
    PRDM2/RIZ1 (PRDM2 Produkte)
    Hintergrund

    Background: PR domain containing 2, with ZNF domain (PRDM2), also known as zinc finger protein RIZ, is a member of histone methyltransferase (HMT) class enzymes that methylate lysine residues of histones or proteins. HMTs contain a conserved catalytic core termed the SET domain, which shares sequence homology with an independently described sequence motif, the PR domain. PRDM2 contains 8 C2H2-type zinc fingers and a distinct SET domain, and is highly expressed in retinoblastoma cell lines and in brain tumors, as well as in a number of other cell lines and in brain, heart, skeletal muscle, liver and spleen. PRDM2 is a S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3, and is identified as a tumor suppressor. It is reported that intact PR( SET) sequence is required for tumor suppression functions, mutations in the PR domain caused activity reduction in human cancers. Also, S-adenosylhomocysteine or methyl donor deficiency inhibits RIZ1 and other H3 lysine 9 methylation activities. PRDM2 may also function as a DNA-binding transcription factor. It Binds to the macrophage-specific TPA-responsive element (MTE) of the HMOX1 (heme oxygenase 1) gene and act as a transcriptional activator. In addition, PRDM2 (RIZ) is able to binds to the retinoblastoma protein (RB) and also Interacts with GATA3.

    Synonym: HUMHOXY1,KMT8,MTB-ZF,RIZ,RIZ1,RIZ2

    Molekulargewicht
    23 kDa
    NCBI Accession
    NP_036363
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