PROCR Protein (His tag)

Produktnummer ABIN7317261

Produktdetails

Target: PROCR (Protein C Receptor, Endothelial (PROCR))

Protein-Typ: Recombinant

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses PROCR Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human EPCR Protein (His Tag)

Sequenz: Met 1-Thr 209

Produktmerkmale: A DNA sequence encoding the extracellular domain of human PROCR (Q9UNN8) (Met 1-Thr 209), was fused with a polyhistidine tag at the C-terminus.

Reinheit: > 97 % as determined by reducing SDS-PAGE.

Endotoxin-Niveau: < 1.0 EU per μg of the protein as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: PROCR (Protein C Receptor, Endothelial (PROCR))

Andere Bezeichnung: EPCR (PROCR Produkte)

Synonyme: PROCR Protein, CCCA Protein, CCD41 Protein, EPCR Protein, AI325044 Protein, Ccca Protein, Ccd41 Protein, Epcr Protein, protein C receptor Protein, protein C receptor, endothelial Protein, PROCR Protein, Procr Protein

Hintergrund:

Background: Endothelial protein C receptor (EPCR); also known as activated protein C receptor (APC receptor) or PROCR; is a receptor for Protein C. Protein C plays an important role in many metabolism processes in humans and other animals after activated by binding to Endothelial protein C receptor (EPCR). Because of the EPCR is found primarily on endothelial cells (cells on the inside of blood vessels); activated protein C is found maily near endothelial cells. Protein C is pleiotropic; with two main functions: anticoagulation and cytoprotection. Which function will be performed depend on whether or not protein C remains bind to EPCR after activated. The anticoagulation occurs when it does not. In this case; protein C functions as an anticoagulant by irreversibly proteolytically inactivating Factor Va and Factor VIIIa; turning them into Factor Vi and Factor VIIIi respectively. When still bound to EPCR; activated protein C performs its cytoprotective effects; acting on the effector substrate PAR-1; protease-activated receptor-1. To a degree; APC's anticoagulant properties are independent of its cytoprotective ones; in that expression of one pathway is not affected by the existence of the other. 

Synonym: Endothelial Protein C Receptor; Activated Protein C Receptor; APC Receptor; Endothelial Cell Protein C Receptor; CD201; PROCR; EPCR

Molekulargewicht: 23.4 kDa

UniProt: Q9UNN8