SEMA4D/CD100 Protein (Fc Tag)
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- Target Alle SEMA4D/CD100 (SEMA4D) Proteine anzeigen
- SEMA4D/CD100 (SEMA4D) (Sema Domain, Immunoglobulin Domain (Ig), Transmembrane Domain (TM) and Short Cytoplasmic Domain, (Semaphorin) 4D (SEMA4D))
- Protein-Typ
- Recombinant
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Spezies
- Maus
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Quelle
- Human Cells
- Aufreinigungstag / Konjugat
- Dieses SEMA4D/CD100 Protein ist gelabelt mit Fc Tag.
- Verwendungszweck
- Recombinant Mouse Semaphorin-4D/SEMA4D Protein (Fc Tag)
- Sequenz
- Phe24-Met711
- Produktmerkmale
- Recombinant Mouse Semaphorin 4D is produced by our Mammalian expression system and the target gene encoding Phe24-Met711 is expressed with a Fc tag at the C-terminus.
- Reinheit
- > 95 % as determined by SDS-PAGE
- Endotoxin-Niveau
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product SEMA4D Protein
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- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Rekonstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from a 0.2 μm filtered solution of 20 mM PB,150 mM NaCl, pH 7.4.
- Lagerung
- 4 °C,-20 °C,-80 °C
- Informationen zur Lagerung
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Target
- SEMA4D/CD100 (SEMA4D) (Sema Domain, Immunoglobulin Domain (Ig), Transmembrane Domain (TM) and Short Cytoplasmic Domain, (Semaphorin) 4D (SEMA4D))
- Andere Bezeichnung
- Semaphorin-4D/SEMA4D (SEMA4D Produkte)
- Synonyme
- C9orf164 Protein, CD100 Protein, M-sema-G Protein, SEMAJ Protein, coll-4 Protein, Semacl2 Protein, Semaj Protein, Semcl2 Protein, COLL-4 Protein, semaphorin 4D Protein, sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D Protein, Sema4d Protein, SEMA4D Protein
- Hintergrund
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Background: SEMA4D is a member of the semaphorin family,contains one Ig-like C2-type domain, one PSI domain and one Sema domain. SEMA4D is strongly expressed in lymphoid tissues, especially in the thymus, as well as in the nervous tissues. However, SEMA4D is expressed at lower levels in testes, brain, kidney, small intestine, prostate, heart, placenta, lung and pancreas, but not in colon and liver. SEMA4D is a cell surface receptor for PLXN1B and PLXNB2 that plays an important role in cell-cell signaling. SEMA4D is involved in a number of fundamental biological processes such as promoting reorganization of the actin cytoskeleton, the migration of cerebellar granule cells and of endothelial cells and signaling via SRC and PTK2B/PYK2, which then mediates activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Not only these, it plays a role in axonal growth cone guidance in the developing central nervous system. Semaphorin-4D / SEMA4D may play a functional role in the immune system, as well as in the nervous system. It could induce B-cells to aggregate and improves their viability (in vitro). SEMA4D is involved in regulating dendrite and axon branching and morphogenesis and promoting interaction with PLXNB1 mediates activation of RHOA.
Synonym: SEMA4D,Semaphorin-4D,M-Sema G,Semaphorin-C-like 2,Semaphorin-J,Sema J,CD100,Semacl2,Semaj,coll-4,Semacl2,Semaj
- Molekulargewicht
- 103.4 kDa
- NCBI Accession
- NP_038688
- Pathways
- Regulation of Cell Size
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