SLAMF6 Protein (His tag)
-
- Target Alle SLAMF6 Proteine anzeigen
- SLAMF6 (SLAM Family Member 6 (SLAMF6))
- Protein-Typ
- Recombinant
- Biologische Aktivität
- Active
-
Spezies
- Maus
-
Quelle
- HEK-293 Cells
- Aufreinigungstag / Konjugat
- Dieses SLAMF6 Protein ist gelabelt mit His tag.
- Verwendungszweck
- Recombinant Mouse SLAMF6/Ly108 Protein (His Tag)(Active)
- Sequenz
- Met 1-Asn 239
- Produktmerkmale
- A DNA sequence encoding the mouse SLAMF6 (NP_109635.1) extracellular domain (Met 1-Asn 239) was fused with a polyhistidine tag at the C-terminus.
- Reinheit
- > 95 % as determined by SDS-PAGE
- Endotoxin-Niveau
- < 1.0 EU per μg of the protein as determined by the LAL method.
- Biological Activity Comment
- Measured by its ability to bind biotinylated recombinant human SH2D1A in a functional ELISA.
- Top Product
- Discover our top product SLAMF6 Protein
-
-
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
- Format
- Lyophilized
- Rekonstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from sterile PBS, pH 7.4
- Lagerung
- 4 °C,-20 °C,-80 °C
- Informationen zur Lagerung
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
-
- Target
- SLAMF6 (SLAM Family Member 6 (SLAMF6))
- Andere Bezeichnung
- SLAMF6/Ly108 (SLAMF6 Produkte)
- Synonyme
- SLAMF6 Protein, CD352 Protein, KALI Protein, KALIb Protein, Ly108 Protein, NTB-A Protein, NTBA Protein, SF2000 Protein, KAL1 Protein, KAL1b Protein, RGD1561848 Protein, SLAM family member 6 Protein, SLAMF6 Protein, Slamf6 Protein
- Hintergrund
-
Background: SLAM family member 6, also known as Activating NK receptor, NK-T-B-antigen, NTB-A, SLAMF6, KALI and Ly108, is a single-pass type I membrane protein which belongs to the CD2 subfamily of the immunoglobulin superfamily. SLAMF6 / Ly108 contains one Ig-like (immunoglobulin-like) domain. It is expressed by all (resting and activated) natural killer cells (NK), T- and B-lymphocytes. SLAMF6 / Ly108 triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors. SLAMF6 / Ly108 is a homodimer. It interacts with PTN6 and, upon phosphorylation, with PTN11 and SH2D1A/SAP. SLAMF6 / Ly108 undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It may function as a coreceptor in the process of NK cell activation. SLAMF6 / Ly108 can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients.
Synonym: KAL1,KAL1b,Ly108,NTB-A,NTBA,SF2000
- Molekulargewicht
- 24.4 kD
- NCBI Accession
- NP_109635
-