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SLAMF6 Protein

SLAMF6 Spezies: Human Wirt: HEK-293 Cells Recombinant > 95 % as determined by reducing SDS-PAGE.
Produktnummer ABIN7317455
  • Target Alle SLAMF6 Proteine anzeigen
    SLAMF6 (SLAM Family Member 6 (SLAMF6))
    Protein-Typ
    Recombinant
    Spezies
    • 15
    • 2
    • 1
    Human
    Quelle
    • 11
    • 2
    • 2
    • 2
    • 1
    HEK-293 Cells
    Verwendungszweck
    Recombinant Human SLAMF6/Ly108 Protein
    Sequenz
    Met 1-Met226
    Produktmerkmale
    A DNA sequence encoding the human SLAMF6 (Q96DU3-1)(Met1-Met226) was expressed with six amino acids (LEVLFQ) at the C-terminus.
    Reinheit
    > 95 % as determined by reducing SDS-PAGE.
    Endotoxin-Niveau
    < 1.0 EU per μg as determined by the LAL method.
    Top Product
    Discover our top product SLAMF6 Protein
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Please refer to the printed manual for detailed information.
    Buffer
    Lyophilized from sterile PBS, pH 7.4
    Lagerung
    4 °C,-20 °C,-80 °C
    Informationen zur Lagerung
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Target
    SLAMF6 (SLAM Family Member 6 (SLAMF6))
    Andere Bezeichnung
    SLAMF6/Ly108 (SLAMF6 Produkte)
    Synonyme
    SLAMF6 Protein, CD352 Protein, KALI Protein, KALIb Protein, Ly108 Protein, NTB-A Protein, NTBA Protein, SF2000 Protein, KAL1 Protein, KAL1b Protein, RGD1561848 Protein, SLAM family member 6 Protein, SLAMF6 Protein, Slamf6 Protein
    Hintergrund

    Background: SLAM family member 6, also known as Activating NK receptor, NK-T-B-antigen, NTB-A, SLAMF6, KALI and Ly108, is a single-pass type I membrane protein which belongs to the CD2 subfamily of the immunoglobulin superfamily. SLAMF6 / Ly108 contains one Ig-like (immunoglobulin-like) domain. It is expressed by all (resting and activated) natural killer cells (NK), T- and B-lymphocytes. SLAMF6 / Ly108 triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors. SLAMF6 / Ly108 is a homodimer. It interacts with PTN6 and, upon phosphorylation, with PTN11 and SH2D1A/SAP. SLAMF6 / Ly108 undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It may function as a coreceptor in the process of NK cell activation. SLAMF6 / Ly108 can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients.

    Synonym: SLAM Family Member 6, Activating NK Receptor, NK-T-B-Antigen, NTB-A, CD352, SLAMF6, KALI, Ly108, NTBA, SF2000

    Molekulargewicht
    23.9 kDa
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