SLITRK1 Protein (His tag)
-
- Target Alle SLITRK1 Proteine anzeigen
- SLITRK1 (SLIT and NTRK-Like Family, Member 1 (SLITRK1))
- Protein-Typ
- Recombinant
- Spezies
- Human
-
Quelle
- HEK-293 Cells
- Aufreinigungstag / Konjugat
- Dieses SLITRK1 Protein ist gelabelt mit His tag.
- Verwendungszweck
- Recombinant Human SLITRK1 Protein (His Tag)
- Sequenz
- Met 1-Ser 616
- Produktmerkmale
- A DNA sequence encoding the extracellular domain (Met 1-Ser 616) of human SLITRK1 (NP_443142.1) was expressed with a C-terminal polyhistidine tag.
- Reinheit
- > 95 % as determined by reducing SDS-PAGE.
- Endotoxin-Niveau
- < 1.0 EU per μg as determined by the LAL method.
-
-
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
- Format
- Lyophilized
- Rekonstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from sterile PBS, pH 7.4
- Lagerung
- 4 °C,-20 °C,-80 °C
- Informationen zur Lagerung
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
-
- Target
- SLITRK1 (SLIT and NTRK-Like Family, Member 1 (SLITRK1))
- Andere Bezeichnung
- SLITRK1 (SLITRK1 Produkte)
- Synonyme
- DKFZp459G0529 Protein, LRRC12 Protein, TTM Protein, 3200001I04Rik Protein, SLIT and NTRK like family member 1 Protein, SLIT and NTRK-like family, member 1 Protein, SLITRK1 Protein, slitrk1 Protein, Slitrk1 Protein
- Hintergrund
-
Background: SLITRK1 (Slit and Trk-like family member 1) is a integral membrane protein belonging to the SLITRK family consists of at least 6 members (SLITRK1-6). They are named and characterized by the presence of two leucine-rich repeats (LRRs) in the extracellular domain similar to those found in a secreted axonal growth-controlling protein, Slit, as well as a C-terminal domain with homology to Trk neurotrophin tyrosine kinase receptors. Expression of SLITRKs are highly restricted to neural tissues, and are identified as the neuronal components modulating the neurite outgrowth. More specifically, SLITRK1 expression is found in the mature neurons of the cerebrum, thalamus and hippocampus, and induces unipolar neurites in cultured neuronal cells. Human SLITRK1 is a 696 amino acid precursor protein, and one truncating frameshift mutation (448 aa) has been linked to Tourette's syndrome, a genetically influenced developmental neuropsychiatric disorder characterized by chronic vocal and motor tics. In addition, all SLITRK genes are differentially expressed in brain tumors, such as astrocytoma, oligodendroglioma, glioblastoma, and are suggested to be useful molecular indicators of brain tumor properties.
Synonym: FLJ54428,KIAA0918,KIAA1910,LRRC12,RP11-395N17.1,SLITRK1,TTM
- NCBI Accession
- NP_443142
-