SORCS1 Protein (His tag)

Produktnummer ABIN7317454

Produktdetails

Target: SORCS1 (Sortilin-Related VPS10 Domain Containing Receptor 1 (SORCS1))

Protein-Typ: Recombinant

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses SORCS1 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human SorCS1 Protein (His Tag)

Sequenz: Ser 111-Ser 1099

Produktmerkmale: A DNA sequence encoding the human SORCS1 (Q8WY21-1) extracellular domain (Ser 111-Ser 1099) was fused with a polyhistidine tag at the C-terminus and a signal peptide at the N-terminus

Reinheit: > 92 % as determined by reducing SDS-PAGE.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: SORCS1 (Sortilin-Related VPS10 Domain Containing Receptor 1 (SORCS1))

Andere Bezeichnung: SorCS1 (SORCS1 Produkte)

Synonyme: hSorCS Protein, Sorcs Protein, mSorCS Protein, sortilin related VPS10 domain containing receptor 1 Protein, sortilin-related VPS10 domain containing receptor 1 Protein, SORCS1 Protein, Sorcs1 Protein

Hintergrund:

Background: VPS10 domain-containing receptor SorCS1, also known as SORCS1 and SORCS, is a single-pass type I  membrane protein which belongs to the SORCS family and SORCS1 subfamily. SORCS1 contains five BNR repeats and one PKD domain. SorCS1 is a member of the Vps10p-domain receptor family comprised of Sortilin, SorCS1, SorCS2, SorCS3, and SorLA. The common characteristic of these receptors is an N-terminal Vps10p domain, which either represents the only module of the luminal/extracellular moiety or is combined with additional domains. Family members play roles in protein transport and signal transduction. The individual receptors bind and internalize a variety of ligands, such as neuropeptides and trophic factors, and Sortilin and SorLA mediate trans-Golgi network-to-endosome sorting. Their prominent neuronal expression, several of the identified ligands, and results support the notion that members of this receptor family have important functions in neurogenesis, plasticity-related processes, and functional maintenance of the nervous system. Sortilin and SorLA mediate intracellular protein trafficking and sorting. SorCS1 binds platelet-derived growth factor-BB (PDGF-BB) and is expressed in isoforms differing only in their cytoplasmic domains. SorCS1 binds platelet-derived growth factor, a growth factor crucial for pericyte recruitment to the microvasculature, and may thus have a role in expanding or maintaining the islet vasculature.

Synonym: hSorCS;RP11-446H13.1

Molekulargewicht: 113 kDa