SORCS1 Protein (His tag)
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- Target Alle SORCS1 Proteine anzeigen
- SORCS1 (Sortilin-Related VPS10 Domain Containing Receptor 1 (SORCS1))
- Protein-Typ
- Recombinant
- Spezies
- Human
- Quelle
- HEK-293 Cells
- Aufreinigungstag / Konjugat
- Dieses SORCS1 Protein ist gelabelt mit His tag.
- Verwendungszweck
- Recombinant Human SorCS1 Protein (His Tag)
- Sequenz
- Ser 111-Ser 1099
- Produktmerkmale
- A DNA sequence encoding the human SORCS1 (Q8WY21-1) extracellular domain (Ser 111-Ser 1099) was fused with a polyhistidine tag at the C-terminus and a signal peptide at the N-terminus
- Reinheit
- > 92 % as determined by reducing SDS-PAGE.
- Endotoxin-Niveau
- < 1.0 EU per μg as determined by the LAL method.
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- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Rekonstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from sterile PBS, pH 7.4
- Lagerung
- 4 °C,-20 °C,-80 °C
- Informationen zur Lagerung
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Target
- SORCS1 (Sortilin-Related VPS10 Domain Containing Receptor 1 (SORCS1))
- Andere Bezeichnung
- SorCS1 (SORCS1 Produkte)
- Synonyme
- hSorCS Protein, Sorcs Protein, mSorCS Protein, sortilin related VPS10 domain containing receptor 1 Protein, sortilin-related VPS10 domain containing receptor 1 Protein, SORCS1 Protein, Sorcs1 Protein
- Hintergrund
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Background: VPS10 domain-containing receptor SorCS1, also known as SORCS1 and SORCS, is a single-pass type I membrane protein which belongs to the SORCS family and SORCS1 subfamily. SORCS1 contains five BNR repeats and one PKD domain. SorCS1 is a member of the Vps10p-domain receptor family comprised of Sortilin, SorCS1, SorCS2, SorCS3, and SorLA. The common characteristic of these receptors is an N-terminal Vps10p domain, which either represents the only module of the luminal/extracellular moiety or is combined with additional domains. Family members play roles in protein transport and signal transduction. The individual receptors bind and internalize a variety of ligands, such as neuropeptides and trophic factors, and Sortilin and SorLA mediate trans-Golgi network-to-endosome sorting. Their prominent neuronal expression, several of the identified ligands, and results support the notion that members of this receptor family have important functions in neurogenesis, plasticity-related processes, and functional maintenance of the nervous system. Sortilin and SorLA mediate intracellular protein trafficking and sorting. SorCS1 binds platelet-derived growth factor-BB (PDGF-BB) and is expressed in isoforms differing only in their cytoplasmic domains. SorCS1 binds platelet-derived growth factor, a growth factor crucial for pericyte recruitment to the microvasculature, and may thus have a role in expanding or maintaining the islet vasculature.
Synonym: hSorCS;RP11-446H13.1
- Molekulargewicht
- 113 kDa
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