Stanniocalcin 1 Protein (STC1) (His tag)

Produktnummer ABIN7319806

Produktdetails

Target: Stanniocalcin 1 (STC1)

Protein-Typ: Recombinant

Spezies: Human

Quelle: Human Cells

Aufreinigungstag / Konjugat: Dieses Stanniocalcin 1 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human Stanniocalcin 1/STC-1 (C-6His)

Sequenz: Thr18-Ala247

Produktmerkmale: Recombinant Human Stanniocalcin 1 is produced by our Mammalian expression system and the target gene encoding Thr18-Ala247 is expressed with a 6His tag at the C-terminus.

Reinheit: >95 % as determined by reducing SDS-PAGE.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: Stanniocalcin 1 (STC1)

Andere Bezeichnung: Stanniocalcin 1/STC-1 (STC1 Produkte)

Synonyme: STC Protein, Stc Protein, stc1 Protein, MGC82280 Protein, STC1 Protein, zgc:153307 Protein, LOC777959 Protein, stanniocalcin 1 Protein, stanniocalcin 1 L homeolog Protein, stanniocalcin 1 S homeolog Protein, STC1 Protein, Stc1 Protein, stc1.L Protein, stc1.S Protein, stc1 Protein, LOC777959 Protein

Hintergrund:

Background: Stanniocalcin 1 (STC-1) is a homodimeric glycoprotein hormone that is involved in calcium and phosphate homeostasis. It was originally identified in bony fishes, where elevation of calcium in serum causes the release of STC from the endocrine glands called the corpuscles of Stannius. STC-1 inhibits the breakdown of PAPP-A, protects cancer cells from apoptosis, reduces tumor size of liver cancers, promotes osteoblast differentiation and inhibits longitudinal bone growth directly at the growth plate. It is also a biomarker of brain and lung cancer progression. STC1 signals through inhibitory G-protein modulates CGRP receptor spatial localization during osteoblastogenesis and may function as a regulatory factor interacting with calcitonin peptide members during bone formation.

Synonym: Stanniocalcin 1, stanniocalcin-1, STC1, STC-1, STCSTC-1

Molekulargewicht: 26.9 kDa

UniProt: P52823

Pathways: Hormone Activity