Thrombomodulin Protein (THBD) (His tag)

Produktnummer ABIN7320771

Dieses Recombinant Thrombomodulin-Protein wird in Human Cells exprimiert.

Kurzübersicht für Thrombomodulin Protein (THBD) (His tag) (ABIN7320771)

Target: Thrombomodulin (THBD)

Protein-Typ: Recombinant

Spezies: Maus

Quelle: Human Cells

Reinheit: > 90 % as determined by reducing SDS-PAGE.

Produktdetails

Aufreinigungstag / Konjugat: Dieses Thrombomodulin Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Mouse Thrombomodulin/THBD Protein (His Tag)

Sequenz: Leu17-Ser517

Produktmerkmale: Recombinant Mouse Thrombomodulin is produced by our Mammalian expression system and the target gene encoding Leu17-Ser517 is expressed with a 6His tag at the C-terminus.

Endotoxin-Niveau: < 1.0 EU per μg as determined by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Frozen, Liquid

Buffer: Supplied as a 0.2 μm filtered solution of 20 mM Tris, 150 mM NaCl, pH 8.0.

Lagerung: -20 °C

Informationen zur Lagerung: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Antigendetails

Target: Thrombomodulin (THBD)

Andere Bezeichnung: Thrombomodulin/THBD

Hintergrund:

Background: Thrombomodulin is also known as CD141 antigen and blood dendritic cell antigen 3 (BDCA3), which is encoded by the THBD gene. The deduced amino acid sequence of mouse THBD predicts a signal peptide (aa 1 to 16) and a mature chain (aa 17 to 577) that consists of the following domains: C-type lectin, EGF-like, transmembrane and cytoplasmic. Mouse THBD is corresponding to the extracellular portion of the type I membrane protein. Predominantly synthesized by vascular endothelial cells, THBD inhibits coagulation and fibrinolysis. It functions as a cell surface receptor and an essential cofactor for active thrombin, which in turn activates protein C and thrombinactivatable fibrinolysis inhibitor (TAFI), also known as carboxypeptidase B2 (CPB2). In addition, THBD gene polymorphisims are associated with human disease and THBD plays a role in thrombosis, stroke, arteriosclerosis, and cancer.

Synonym: Thrombomodulin, TM, Fetomodulin, CD141, BDCA-3, Thbd

Molekulargewicht: 54.6 kDa

UniProt: P15306