TWF1 Protein
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- Target Alle TWF1 Proteine anzeigen
- TWF1 (Twinfilin, Actin-Binding Protein 1 (TWF1))
- Protein-Typ
- Recombinant
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Spezies
- Human
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Quelle
- Escherichia coli (E. coli)
- Verwendungszweck
- Recombinant Human TWF1/Twinfilin-1 Protein
- Sequenz
- Met 1-Asp 252
- Produktmerkmale
- A DNA sequence encoding the human TWF1 isoform 4 (Q12792-4) (Met 1-Asp 252) was expressed and purified, with additional two amino acids (Gly & Pro) at the N-terminus.
- Reinheit
- > 94 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product TWF1 Protein
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- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Rekonstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from sterile PBS, pH 7.4, 10 % glycerol
- Lagerung
- 4 °C,-20 °C,-80 °C
- Informationen zur Lagerung
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Target
- TWF1 (Twinfilin, Actin-Binding Protein 1 (TWF1))
- Andere Bezeichnung
- TWF1/Twinfilin-1 (TWF1 Produkte)
- Hintergrund
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Background: Twinfilin-1; also known as Protein A6; Protein tyrosine kinase 9; TWF1 and PTK9; is a cytoplasm protein which belongs to the actin-binding proteins ADF family and Twinfilin subfamily. Twinfilin-1 (TWF1 / PTK9 ) is a highly conserved actin monomer-binding protein that regulates cytoskeletal dynamics in organisms from yeast to mammals. In addition to the mammalian twinfilin-1; a second protein with approximately 65% sequence identity to twinfilin-1 exists in mouse and humans. TWF1 / PTK9 is expressed at high levels in the colon; testis; ovary; prostate and lung. It is expressed at lower levels in the brain; bladder and heart. It is not detected in liver. TWF1 / PTK9 is an actin-binding protein involved in motile and morphological processes. It inhibits actin polymerization; likely by sequestering G-actin. By capping the barbed ends of filaments; it also regulates motility. TWF1 / PTK9 seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles.
Synonym: A6;MGC23788;MGC41876;PTK9
- Molekulargewicht
- 29 kDa
- Pathways
- Regulation of Actin Filament Polymerization, Maintenance of Protein Location
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