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VNN1 Protein (Fc Tag)

VNN1 Spezies: Maus Wirt: HEK-293 Cells Recombinant > 96 % as determined by SDS-PAGE
Produktnummer ABIN7320102
  • Target Alle VNN1 Proteine anzeigen
    VNN1 (Vanin 1 (VNN1))
    Protein-Typ
    Recombinant
    Spezies
    • 9
    • 3
    • 2
    • 1
    • 1
    • 1
    Maus
    Quelle
    • 8
    • 3
    • 2
    • 2
    • 2
    HEK-293 Cells
    Aufreinigungstag / Konjugat
    Dieses VNN1 Protein ist gelabelt mit Fc Tag.
    Verwendungszweck
    Recombinant Mouse VNN1/Vanin-1 Protein (Fc Tag)
    Sequenz
    Met 1-Ser 487
    Produktmerkmale
    A DNA sequence encoding the mouse VNN1 (Q9Z0K8) (Met 1-Ser 487), without the pro peptide, was fused with the Fc region of human IgG1 at the C-terminus.
    Reinheit
    > 96 % as determined by SDS-PAGE
    Endotoxin-Niveau
    < 1.0 EU per μg of the protein as determined by the LAL method.
    Top Product
    Discover our top product VNN1 Protein
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Please refer to the printed manual for detailed information.
    Buffer
    Lyophilized from sterile PBS, pH 7.4
    Lagerung
    4 °C,-20 °C,-80 °C
    Informationen zur Lagerung
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Target
    VNN1 (Vanin 1 (VNN1))
    Andere Bezeichnung
    VNN1/Vanin-1 (VNN1 Produkte)
    Synonyme
    HDLCQ8 Protein, Tiff66 Protein, V-1 Protein, hdlcq8 Protein, tiff66 Protein, vnn1.1 Protein, vanin-1 Protein, vanin 1 Protein, pantetheinase Protein, VNN1 Protein, Vnn1 Protein, vnn1 Protein, LOC100217969 Protein
    Hintergrund

    Background: Pantetheinase, also known as Pantetheine hydrolase, Vascular non-inflammatory molecule 1, Vanin-1, and VNN1, is a cell membrane protein which belongs to the CN hydrolase family and BTD/VNN subfamily. Vanin-1 contains one CN hydrolase domain. It is widely expressed with higher expression in spleen, kidney and blood. It is overexpressed in lesional psoriatic skin. Vanin-1 is also a member of the Vanin family of proteins which share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. Vanin-1 is an epithelial pantetheinase that provides cysteamine to tissue and regulates response to stress. Vanin-1 is expressed by enterocytes, and its absence limits intestinal epithelial cell production of proinflammatory signals. Vanin-1 regulates late adhesion steps of thymus homing under physiological, noninflammatory conditions. The early impact of vanin-1 deficiency on tumor induction was directly correlated to the amount of inflammation and subsequent epithelial proliferation rather than cell death rate. Vanin-1 Molecule was shown to be involved in the control of thymus reconstitution following sublethal irradiation.

    Synonym: V-1

    Molekulargewicht
    79 kDa
    UniProt
    Q9Z0K8
    Pathways
    Negative Regulation of intrinsic apoptotic Signaling
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