VTCN1 Protein (His tag)
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- Target Alle VTCN1 Proteine anzeigen
- VTCN1 (V-Set Domain Containing T Cell Activation Inhibitor 1 (VTCN1))
- Protein-Typ
- Recombinant
- Biologische Aktivität
- Active
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Spezies
- Rhesusaffen
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Quelle
- Human Cells
- Aufreinigungstag / Konjugat
- Dieses VTCN1 Protein ist gelabelt mit His tag.
- Verwendungszweck
- Recombinant Rhesus macaque B7-H4/VTCN1 Protein (His Tag)
- Sequenz
- Phe29-Ala258
- Produktmerkmale
- Recombinant Rhesus macaque B7-H4 is produced by our Mammalian expression system and the target gene encoding Phe29-Ala258 is expressed with a 6His tag at the C-terminus.
- Reinheit
- > 95 % as determined by reducing SDS-PAGE.
- Endotoxin-Niveau
- < 1.0 EU per μg as determined by the LAL method.
- Biological Activity Comment
- Immobilized Human GFRA1-His(Cat: PKSH033670) at 0.5μg/ml(100 μl/well) can bind Human GDNF. The ED50 of GDNF is 14.73ug/ml.
- Top Product
- Discover our top product VTCN1 Protein
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- Kommentare
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40-60 kDa
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Rekonstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
- Lagerung
- 4 °C,-20 °C,-80 °C
- Informationen zur Lagerung
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Target
- VTCN1 (V-Set Domain Containing T Cell Activation Inhibitor 1 (VTCN1))
- Andere Bezeichnung
- B7-H4/VTCN1 (VTCN1 Produkte)
- Synonyme
- B7h4 Protein, B7s1 Protein, B7x Protein, BC032925 Protein, B7-H4 Protein, B7H4 Protein, B7S1 Protein, B7X Protein, B7h.5 Protein, PRO1291 Protein, VCTN1 Protein, RGD1311204 Protein, V set domain containing T cell activation inhibitor 1 L homeolog Protein, V-set domain containing T cell activation inhibitor 1 Protein, V-set domain containing T-cell activation inhibitor 1 Protein, V set domain containing T cell activation inhibitor 1 Protein, vtcn1.L Protein, VTCN1 Protein, vtcn1 Protein, Vtcn1 Protein
- Hintergrund
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Background: B7 Homolog 4 (B7-H4) is glycosylated member of the B7 family of immune costimulatory proteins.It is widely expressed, including in kidney, liver, lung, pancreas, placenta, prostate, spleen, testis and thymus. B7-H4 negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. It also involved in promoting epithelial cell transformation.
Synonym: B7S1, B7x, Vtcn1, B7h.5, B7-H4, B7H4T-cell costimulatory molecule B7x, B7S1VCTN1, B7XPRO1291, FLJ22418, Immune costimulatory protein B7-H4, Protein B7S1, T cell costimulatory molecule B7x, V-set domain containing T cell activation inhibitor 1, V-set domain-containing T-cell activation inhibitor 1
- Molekulargewicht
- 26.4 kDa
- UniProt
- F7B770
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