CD28 Protein (CD28) (Biotin)
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- Target Alle CD28 Proteine anzeigen
- CD28
- Protein-Typ
- Recombinant
- Biologische Aktivität
- Active
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Spezies
- Human, Cynomolgus
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Quelle
- Human Cells
- Aufreinigungstag / Konjugat
- Dieses CD28 Protein ist gelabelt mit Biotin.
- Verwendungszweck
- Recombinant Human/Cynomolyus CD28/TP44 (C-Fc-Avi) Biotinylated
- Sequenz
- Asn19-Pro152
- Produktmerkmale
- Biotinylated Recombinant Human T-cell-specific surface glycoprotein CD28 is produced by our Mammalian expression system and the target gene encoding Asn19-Pro152 is expressed with a Fc, Avi tag at the C-terminus.
- Reinheit
- >95 % as determined by reducing SDS-PAGE.
- Endotoxin-Niveau
- < 1.0 EU per μg as determined by the LAL method.
- Biological Activity Comment
- Immobilized Anti-CD28 mAb(Cat#A063) at 2μg/ml (100 μl/well) can bind Human/Cynomolgus CD28-Fc-Avi(Cat#CY34). The ED50 of Human/Cynomolgus CD28-Fc-Avi(Cat#CY34) is 0.84 ng/ml.
- Top Product
- Discover our top product CD28 Protein
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- Kommentare
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60-90 kDa
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Rekonstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from a 0.2 μm filtered solution of 20mTris-HCl, 150 mM NaCl, pH 8.0.
- Lagerung
- 4 °C,-20 °C,-80 °C
- Informationen zur Lagerung
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Target
- CD28
- Andere Bezeichnung
- CD28 (CD28 Produkte)
- Synonyme
- Tp44 Protein, CD28RNA Protein, cd28 Protein, CD28 molecule Protein, CD28 antigen Protein, Cd28 molecule Protein, CD28 molecule L homeolog Protein, CD28 Protein, Cd28 Protein, cd28.L Protein
- Hintergrund
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Background: T-cell-specific surface glycoprotein CD28(CD28) is a single-pass typeI membrane protein which contains one Ig-likeV-type (immunoglobulin-like) domain. It belongs to the immunoglobulin(Ig) superfamily. CD28 is one of the molecules expressed on T cells that provide co-stimulatory signals, which are required for T cell activation.CD28 co-stimulation is necessary for CD4 positive T-cell proliferation and survival, interleukin-2 production, and T-helper type-2 development. Human post-thymic regulatory T cells require CD28 co-stimulation to expand and maintain potent suppressive function in vivo. Apoptosis plays a key role in the age-related decline of CD28 expression and in immunosenescence. CD28 is the receptor for CD80 (B7.1) and CD86 (B7.2). When activated by Toll-like receptor ligands, the CD80 expression is upregulated in antigen presenting cells (APCs). The CD86 expression on antigen presenting cells is constitutive. CD28 is the only B7 receptor constitutively expressed on naive T cells.
Synonym: CD28, CD28 antigen, CD28 Molecule, T-cell-specific surface glycoprotein CD28, Tp44, TP44
- Molekulargewicht
- 44.1 kDa
- UniProt
- P10747
- Pathways
- T-Zell Rezeptor Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response
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