Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

PEA15 Protein

PEA15 Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant > 95 % as determined by reducing SDS-PAGE.
Produktnummer ABIN7318180
  • Target Alle PEA15 Proteine anzeigen
    PEA15 (phosphoprotein Enriched in Astrocytes 15 (PEA15))
    Protein-Typ
    Recombinant
    Spezies
    • 4
    • 1
    Human
    Quelle
    • 2
    • 1
    • 1
    • 1
    Escherichia coli (E. coli)
    Verwendungszweck
    Recombinant Human Astrocytic Phosphoprotein PEA-15/PEA15 Protein
    Sequenz
    Met 1-Ala130
    Produktmerkmale
    Recombinant Human Phosphoprotein Enriched in Astrocytes of 15 kDa is produced by our E.coli expression system and the target gene encoding Met1-Ala130 is expressed.
    Reinheit
    > 95 % as determined by reducing SDS-PAGE.
    Endotoxin-Niveau
    < 1.0 EU per μg as determined by the LAL method.
    Top Product
    Discover our top product PEA15 Protein
  • Kommentare

    12-16 kDa

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Please refer to the printed manual for detailed information.
    Buffer
    Lyophilized from a 0.2 μm filtered solution of 20 mM PB,150 mM NaCl, pH 7.4.
    Lagerung
    4 °C,-20 °C,-80 °C
    Informationen zur Lagerung
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Target
    PEA15 (phosphoprotein Enriched in Astrocytes 15 (PEA15))
    Andere Bezeichnung
    PEA15 (PEA15 Produkte)
    Synonyme
    HMAT1 Protein, HUMMAT1H Protein, MAT1 Protein, MAT1H Protein, PEA-15 Protein, PED Protein, Pea15a Protein, PEA15 Protein, DKFZp459O1410 Protein, proliferation and apoptosis adaptor protein 15 Protein, phosphoprotein enriched in astrocytes 15 Protein, proliferation and apoptosis adaptor protein 15 L homeolog Protein, Astrocytic phosphoprotein PEA-15 Protein, PEA15 Protein, Pea15 Protein, pea15.L Protein, pea15 Protein
    Hintergrund

    Background: Astrocyticphosphoprotein PEA-15 (PEA15) is a death effector domain (DED)-containing protein. PEA15 is mainly expressed in the central nervous system, principally in astrocytes. Increased PEA15 levels affect tumorigenesis and cancer progression. PEA15 is overexpressed in breast cancers and gliomas as well as in type 2 diabetes. PEA15 blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. PEA15 also inhibits RPS6KA3 activities by holding it in the cytoplasm. In addition, PEA15 inhibits both TNFRSF6 and TNFRSF1A mediated CASP8 activity and apoptosis. At present, PEA15 expression is also a significant prognostic marker in ovarian cancer.

    Synonym: Astrocytic Phosphoprotein PEA-15, 15 kDa Phosphoprotein Enriched in Astrocytes, Phosphoprotein Enriched in Diabetes, PED, PEA15

    Molekulargewicht
    15.3 kDa
    UniProt
    Q15121
Sie sind hier:
Kundenservice