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HLA-B*27:05 protein (SBP Tag)

Spezies: Human Wirt: Mammalian Cells Recombinant > 80 % BP, CP, ELISA, Neut
Produktnummer ABIN7273193
  • Target
    HLA-B*27:05
    Protein-Typ
    Recombinant
    Spezies
    Human
    Quelle
    Mammalian Cells
    Aufreinigungstag / Konjugat
    SBP Tag
    Applikation
    Blocking Peptide (BP), Control Peptide (CP), ELISA, Neutralization (Neut)
    Verwendungszweck
    The product is HLA-B*27:05 complexed with β2-microglobulin (b2m)
    Sequenz
    heavy chain: GSHSMRYFHT SVSRPGRGEP RFITVGYVDD TLFVRFDSDA ASPREEPRAP WIEQEGPEYW DRETQICKAK AQTDREDLRT LLRYYNQSEA GSHTLQNMYG CDVGPDGRLL RGYHQDAYDG KDYIALNEDL SSWTAADTAA QITQRKWEAA RVAEQLRAYL EGECVEWLRR YLENGKETLQ RADPPKTHVT HHPISDHEAT LRCWALGFYP AEITLTWQRD GEDQTQDTEL VETRPAGDRT FQKWAAVVVP SGEEQRYTCH VQHEGLPKPL TLRWEPSSQS TVPI
    light chain: IQRTPKIQVY SRHPAENGKS NFLNCYVSGF HPSDIEVDLL KNGERIEKVE HSDLSFSKDW SFYLLYYTEF TPTEKDEYAC RVNHVTLSQP KIVKWDRDM
    Sequences without tags. Tag location is at the discretion of the manufacturer.
    Spezifität
    HLA-B*27:05 complexed with b2m, P01889 / P61769
    HLA-B*27:05 is associated with a higher incidence of ankylosing spondylitis in Caucasians and is therefore of great interest to HLA researchers. HLA-B*27:05 is recognized by anti-Bw4 antibodies.
    Produktmerkmale
    HLAs are produced in mammalian cell cultures as recombinant, truncated, soluble antigens, in complex with β2-microglobulin (HLA class I). As part of our quality control, all HLA are analyzed for purity by gel electrophoresis, concentration is determined by ELISA (0.5 mg/ml) and their functionality is verified with a specific antiserum.
    Aufreinigung
    Chromatography
    Reinheit
    > 80 %
    Endotoxin-Niveau
    Endotoxins have not been removed
  • Applikationshinweise
    ELISA: 1 - 100 ng/mL
    Kommentare

    sandwich ELISA, direct ELISA, bead ELISA, reactive with antibodies W6/32 and BBM.1 and specific antiserum, B cell ELI Spot (predicted), in vitro memory B cell stimulation (predicted), HLA competition assay (predicted), control in various assays (predicted)

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    0.5 mg/mL
    Buffer
    TRIS based buffer, pH 8.0, Sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
    Haltbarkeit
    6 months
  • Target
    HLA-B*27:05
    Hintergrund
    Human Leukozyte Antigen, human Antigen-presenting major histocompatibility complex class I (MHCI) molecule. Expressed on all cells, displays peptides to CD8-positive T cells. Involved in cellular immune response.
    Molekulargewicht
    approx. 50 kDa (38 kDa heavy chain + 12 kDa b2m)
    UniProt
    P01889
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