CD96 Protein (CD96) (Cys110Ser-Mutant) (His tag)
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- Target Alle CD96 Proteine anzeigen
- CD96
- Protein-Typ
- Recombinant
- Proteineigenschaft
- Cys110Ser-Mutant
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Spezies
- Human
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Quelle
- HEK-293 Cells
- Aufreinigungstag / Konjugat
- Dieses CD96 Protein ist gelabelt mit His tag.
- Verwendungszweck
- Human CD96/TACTILE (C110S) Protein
- Sequenz
- Val22-Met503 (C110S)
- Produktmerkmale
- Recombinant Human CD96/TACTILE (C110S) Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Val22-Met503(C110S).
- Reinheit
- > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
- Sterilität
- 0.22 μm filtered
- Endotoxin-Niveau
- Less than 1EU per μg by the LAL method.
- Biological Activity Comment
- Immobilized Human CD96 (C110S) , His Tag at 1μg/ml (100μl/well) on the plate. Dose response curve for Anti-CD96 Antibody, hFc Tag with the EC50 of 0.17ug/ml determined by ELISA. See testing image for detail.
- Top Product
- Discover our top product CD96 Protein
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- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Rekonstitution
- Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.
- Buffer
- Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.
- Lagerung
- -20 °C,-80 °C
- Informationen zur Lagerung
- -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
- Haltbarkeit
- 12 months
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- Target
- CD96
- Andere Bezeichnung
- CD96 (CD96 Produkte)
- Hintergrund
- The receptors CD96 and TIGIT are expressed on the surface of T and natural killer (NK) cells, and recent studies suggest both play important inhibitory roles in immune function. CD96 has been shown to modulate immune cell activity in mice, with Cd96-/- mice displaying hypersensitive NK-cell responses to immune challenge and significant tumor resistance. The counterbalance between the putative inhibitory CD96 and TIGIT receptors and the activating receptor, CD226, offers unique strategies for immuno-oncology drug development.
- Molekulargewicht
- 54.63 kDa. Due to glycosylation, the protein migrates to 100-130 kDa based on Tris-Bis PAGE result.
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