DLL1 Protein (AA 18-540) (His tag)
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- Target Alle DLL1 Proteine anzeigen
- DLL1 (delta-Like 1 (DLL1))
- Protein-Typ
- Recombinant
- Proteineigenschaft
- AA 18-540
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Spezies
- Human
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Quelle
- HEK-293 Cells
- Aufreinigungstag / Konjugat
- Dieses DLL1 Protein ist gelabelt mit His tag.
- Verwendungszweck
- Human DLL1/Delta1 Protein
- Sequenz
- Gln18-Gly540
- Produktmerkmale
- Recombinant Human DLL1/Delta1 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Gln18-Gly540.
- Reinheit
- > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
- Sterilität
- 0.22 μm filtered
- Endotoxin-Niveau
- Less than 1EU per μg by the LAL method.
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- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Rekonstitution
- Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.
- Buffer
- Lyophilized from 0.22μm filtered solution in 50 mM Tris, 150 mM NaCl ( pH 7.5). Normally 8 % trehalose is added as protectant before lyophilization.
- Lagerung
- -20 °C,-80 °C
- Informationen zur Lagerung
- -20 to -80°C for 12 months as supplied from date of receipt., -80°C for 3-6 months after reconstitution., 2-8°C for 2-7 days after reconstitution., Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
- Haltbarkeit
- 12 months
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- Target
- DLL1 (delta-Like 1 (DLL1))
- Andere Bezeichnung
- DLL1 (DLL1 Produkte)
- Synonyme
- X-delta-1 Protein, XDelta1 Protein, Xdelta-1 Protein, delta Protein, delta-1 Protein, delta1 Protein, x-delta Protein, DELTA1 Protein, DL1 Protein, Delta Protein, DLK Protein, DLK-1 Protein, Delta1 Protein, FA1 Protein, PREF1 Protein, Pref-1 Protein, ZOG Protein, pG2 Protein, DLL1 Protein, AW742678 Protein, DlkI Protein, Ly107 Protein, Peg9 Protein, SCP1 Protein, pref-1 Protein, delta-like 1 Protein, delta like canonical Notch ligand 1 Protein, delta like non-canonical Notch ligand 1 Protein, delta-like 1 L homeolog Protein, delta-like 1 (Drosophila) Protein, delta-like 1 homolog (Drosophila) Protein, dll1 Protein, DLL1 Protein, DLK1 Protein, Dll1 Protein, dll1.L Protein, Dlk1 Protein
- Hintergrund
- DLL1, a Notch signaling ligand, is significantly overexpressed in ERα luminal breast cancer. Intriguingly, DLL1 overexpression correlates with poor prognosis in ERα luminal breast cancer, but not in other subtypes of breast cancer. In addition, this effect is specific to DLL1, as other Notch ligands (DLL3, JAGGED1, and JAGGED2) do not influence the clinical outcome of ERα patients. DLL1-mediated Notch signaling in breast cancer is important for tumor cell proliferation, angiogenesis, and cancer stem cell function.
- Molekulargewicht
- 57.6 kDa. Due to glycosylation, the protein migrates to 60-70 kDa based on Tris-Bis PAGE result.
- NCBI Accession
- NP_005609
- Pathways
- Notch Signalweg, Stem Cell Maintenance
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