PAD4 (PADI4)
(Peptidyl Arginine Deiminase, Type IV (PADI4))
Protein-Typ
Recombinant
Proteineigenschaft
AA 1-663
Spezies
Cynomolgus
Quelle
Escherichia coli (E. coli)
Aufreinigungstag / Konjugat
Dieses PAD4 Protein ist gelabelt mit His tag,Biotin.
Verwendungszweck
Biotinylated Cynomolgus PADI4 Protein (Primary Amine Labeling)
Sequenz
Met1-Pro663
Produktmerkmale
Recombinant Biotinylated Cynomolgus PADI4 Protein (Primary Amine Labeling) is expressed from E.coli with His tag at the N-Terminus.It contains Met1-Pro663.
PADI4
Spezies: Human
Wirt: Tobacco (Nicotiana tabacum)
Recombinant
>80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot.
WB, SDS, ELISA
Supplied as 0.22μm filtered solution in 20 mM Tris, 500 mM NaCl, 10 % Glycerol, 0.5 mM TCEP, 1 mM EDTA ( pH 8.0).
Konservierungsmittel
Other preservative
Lagerung
-80 °C
Informationen zur Lagerung
Valid for 12 months from date of receipt when stored at -80°C.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Haltbarkeit
12 months
Target
PAD4 (PADI4)
(Peptidyl Arginine Deiminase, Type IV (PADI4))
PAD Protein, PAD4 Protein, PADI5 Protein, PDI4 Protein, PDI5 Protein, Pad4 Protein, Pdi4 Protein, peptidyl arginine deiminase 4 Protein, peptidyl arginine deiminase, type IV Protein, PADI4 Protein, Padi4 Protein
Hintergrund
Peptidylarginine deiminase type4 (PADI4) was firstly identified as a non-MHC RA genetic risk factor. Furthermore, PADI4 risk allele possessed the association with bone damage regardless of anti citrullinated peptide antibody (ACPA) positivity in Asian RA patients. PADI4 gene codes PAD4 protein which has post-translational modification activity (citrullination). Padi4 is mainly expressed in myeloid cells and granulocytes.