Complement C2 Protein (His tag)

Produktnummer ABIN7447953

Produktdetails

Target: Complement C2

Protein-Typ: Recombinant

Biologische Aktivität: Active

Spezies: Cynomolgus

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses Complement C2 Protein ist gelabelt mit His tag.

Verwendungszweck: Cynomolgus Complement C2 Protein, His Tag (active enzyme)

Sequenz: Ala 21 - Leu 752

Produktmerkmale: Cynomolgus Complement C2, His Tag is expressed from human 293 cells (HEK293). It contains AA Ala 21 - Leu 752 (Accession # G8F3W0-1).

Reinheit: 95,00 %

Endotoxin-Niveau: 1.0 EU per μg

Biological Activity Comment: Measured by its ability to cleave a colorimetric peptide substrate, N-carbobenzyloxy-Gly-Arg-ThioBenzyl ester (Z-GR-SBzl), in the presence of 5,5’Dithio-bis (2-nitrobenzoic acid) (DTNB).The specific activity is >100 pmol/min/µg (QC tested).

Anwendungsinformationen

Kommentare:

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 83.0 kDa. The protein migrates as 90-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 20 mM Tris,150 mM NaCl,Ph 7.5

Lagerung: -20 °C

Informationen zur Lagerung: -20°C

Antigendetails

Target: Complement C2

Abstract: Complement C2 Produkte

Synonyme: CO2 Protein, complement C2 Protein, complement component 2 (within H-2S) Protein, C2 Protein

Hintergrund: Synonyms:C2,Complement C2,Complement Component C2,Description:C2 is a major histocompatibility complex class-III protein. Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase. The lectin (LP) and classical (CP) pathways are two of the three main activation cascades of the complement system. These pathways start with recognition of different pathogen- or danger-associated molecular patterns and include identical steps of proteolytic activation of complement component C4, formation of the C3 proconvertase C4b2, followed by cleavage of complement component C2 within C4b2 resulting in the C3 convertase C4b2a.

Molekulargewicht: 83.0 kDa

NCBI Accession: XP_005553508