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CCR2 Protein-VLP (AA 1-360)

CCR2 Spezies: Human Wirt: HEK-293 Cells VLP > 95 % as determined by HPLC ELISA, Imm, Func, SPR Active
Produktnummer ABIN7448153
  • Target Alle CCR2 Proteine anzeigen
    CCR2 (Chemokine (C-C Motif) Receptor 2 (CCR2))
    Protein-Typ
    VLP
    Biologische Aktivität
    Active
    Proteineigenschaft
    AA 1-360
    Spezies
    • 9
    • 2
    Human
    Quelle
    • 4
    • 2
    • 2
    • 2
    • 1
    HEK-293 Cells
    Applikation
    ELISA, Immunogen (Imm), Functional Studies (Func), Surface Plasmon Resonance (SPR)
    Verwendungszweck
    Human CCR2b Protein-VLP
    Sequenz
    Met1-Leu360
    Produktmerkmale
    Recombinant Human CCR2b Protein-VLP is expressed from HEK293.It contains Met1-Leu360.
    Reinheit
    > 95 % as determined by HPLC
    Sterilität
    0.22 μm filtered
    Endotoxin-Niveau
    Less than 1EU per μg by the LAL method.
    Biological Activity Comment
    Immobilized Human CCR2b VLP at 5μg/ml (100μl/Well) on the plate. Dose response curve for Anti-CCR2b Antibody, hFc Tag with the EC50 of 12.0ng/ml determined by ELISA.
    Top Product
    Discover our top product CCR2 Protein
  • Applikationshinweise
    • Antibody Discovery: Immunization, Screening, Functional Characterization
    • Affinity determination: ELISA, SPR
    • In vivo pharmacokinetic analysis
    • CMC method development
    • CAR-T Positive Rate Detection
    • Blood sample determination: ELISA
    Kommentare

    Virus-like particles (VLPs) are formed from the outer capsid protein of a virus and are tiny nanoparticles formed by the automatic assembly of one or more capsid proteins. VLPs do not contain viral infectious genomes, so they are relatively safe during production operations. The SAMS™ protein engineering platform has been used to express a series of biotinylated, non-biotinylated, and fluorescently-labeled VLP-displayed antigens. They are suitable for SPR, ELISA, CAR-T positive rate detection, and other experimental scenarios.

    Virus-Like Particles (VLPs) are highly immunogenic, meaning that they can elicit a strong immune response in the host. VLPs are recognized by the immune system and are taken up by antigen-presenting cells (APCs) such as dendritic cells. Once taken up by APCs, VLPs are processed and presented to T cells, which can trigger the activation of B cells to produce antibodies against the displayed antigen. Because VLPs resemble the structure and composition of native viruses, they are highly effective at inducing both humoral and cellular immune responses.

    Generally, VLPs range in size from approximately 20 to 200 nanometers (nm). Compared to a cell-based immunization approach, their smaller size can optimize the immune response to target the specific antigen displayed on the surface of the engineered VLPs.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Supplied as 0.22μm filtered solution in PBS ( pH 7.4). Notice: If you need it for immunization, Do Not use any adjuvant.
    Lagerung
    -80 °C
    Informationen zur Lagerung
    Valid for 12 months from date of receipt when stored at -80°C., Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
    Haltbarkeit
    12 months
  • Target
    CCR2 (Chemokine (C-C Motif) Receptor 2 (CCR2))
    Andere Bezeichnung
    CCR2b (CCR2 Produkte)
    Synonyme
    CC-CKR-2 Protein, CCR-2 Protein, CCR2A Protein, CCR2B Protein, CD192 Protein, CKR2 Protein, CKR2A Protein, CKR2B Protein, CMKBR2 Protein, MCP-1-R Protein, ACKR5 Protein, CKRX Protein, CRAM Protein, CRAM-A Protein, CRAM-B Protein, HCR Protein, Cc-ckr-2 Protein, Ccr2a Protein, Ccr2b Protein, Ckr2 Protein, Ckr2a Protein, Ckr2b Protein, Cmkbr2 Protein, mJe-r Protein, C-C motif chemokine receptor 2 Protein, C-C motif chemokine receptor like 2 Protein, chemokine (C-C motif) receptor 2 Protein, CCR2 Protein, CCRL2 Protein, Ccr2 Protein, LOC484790 Protein
    Hintergrund
    The chemokine (C-C motif) receptor 2B (CCR2B) is one of the two isoforms of the receptor for monocyte chemoattractant protein-1 (CCL2), the major chemoattractant for monocytes, involved in an array of chronic inflammatory diseases. The actin-binding protein filamin A (FLNa) as a protein that associates with the carboxyl-terminal tail of CCR2B. FLNa emerges as an important protein for controlling the internalization and spatial localization of the CCR2B receptor in different dynamic membrane structures.
    Molekulargewicht
    42.9kDa.
    Pathways
    cAMP Metabolic Process, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
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