IL18BP Protein (AA 31-192) (Fc Tag)

Produktnummer ABIN7490683

Produktdetails

Target: IL18BP (Interleukin 18 Binding Protein (IL18BP))

Protein-Typ: Recombinant

Proteineigenschaft: AA 31-192

Spezies: Hund

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses IL18BP Protein ist gelabelt mit Fc Tag.

Verwendungszweck: Recombinant Canis IL18BP protein with C-terminal human Fc tag

Spezifität: IL18BP (Thr31-Phe192) hFc (Glu99-Ala330)

Produktmerkmale: Extracellular Domain Protein

Aufreinigung: Purified from cell culture supernatant by affinity chromatography

Reinheit: The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Haltbarkeit: 12 months

Antigendetails

Target: IL18BP (Interleukin 18 Binding Protein (IL18BP))

Andere Bezeichnung: IL18BP (IL18BP Produkte)

Synonyme: IL18BP Protein, IL-18BP Protein, Igifbp Protein, MC54L Protein, IL18BPa Protein, interleukin 18 binding protein Protein, IL18BP Protein, Il18bp Protein

Hintergrund: Interleukin-18-binding protein (IL-18BP) is a constitutively expressed and secreted protein. IL-18BP is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18) and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q. The adjacently located family members IL18 Receptor 1 (IL18R1) and IL18 receptor accessory protein (IL18RAP) may also be important in the development of asthma and atopy. IL-18 binding protein (IL-18BP) was only moderately elevated, resulting in a high level of biologically active free IL-18 in HPS. A severe IL-18/IL-18BP imbalance results in Th-1 lymphocyte and macrophage activation, which escapes control by NK-cell cytotoxicity and may allow for secondary HPS in patients with underlying diseases.

Molekulargewicht: predicted molecular mass of 43.7 kDa after removal of the signal peptide.The apparent molecular mass of dIL18BP-hFc is 55-70 kDa due to glycosylation.

UniProt: F1PLB5